The autoadaptation mechanism of the human body loses its rationality and purposefulness by an imblance of the autonomic nervous system, and the host body falls into adaptational disturbances. Hosts with sympathicotonia often fall into acute adaptational disturbances in the acme to the convalescent stage by stimuli of the second-phase factors (the factors lowering mitosis of the neutropoietic system in the bone marrow), resulting sometimes in death. Infectious factors such as salmonella (typhoid and paratyphoid bacilli), rickettiae, viruses, etc., physico-chemical factors such as alkalis and alkaline substances, benzene and its derivatives, X-ray and other radio-active substances belong to the second-phase factor. On the contrary, hosts with parasympathicotonia often fall into acute adaptational disturbances in the initial stage to the acme by stimuli of the first-phase factors (the factors raising mitosis of the neutropoietic system in the bone marrow). The disturbances are prominent, particularly, in the early stage of stimulation and recognized as shock. Infectious factors such as cocci and shigella, chemical factors such as foreign proteins, acids and acid substances belong to the first-phase factor.
Hosts with parasympathicotonia are resistant against the second-phase factors such as typhoid bacilli, but weak against the first-phase factors such as cocci, on the contrary, hosts with sympathicotonia show strong resistance againt the firstphase factors such as cocci, but weak against the second-phase factors such as typhoid bacilli.