Purpose
to correlate the dynamic susceptibility contrast percentage (DSC%) of pharyngeal squamous cell carcinoma with prognostic parameters.
Methods and Materials
Patients:• 31 consecutive patients (22M, 9F)• Aged 47-73 ys: mean 61ys• 1.5 tesla scanner with single shot EPI.Methods:• Routine MR (T1,T2WI) (n=31).• DSC perfusion MRI (n=31).• Routine post contrast study (n=31).Data AcquisitionMR Machine:• 1.5 tesla MR unit (symphony-Siemens).• Gradient strength: 30mTm.• slew rate: 120 T/m/s.Single Shot DSC T2*WI:• TR:120 ms, TE:47ms.• NEX:1, Slice thick: 5mm.• Slice no: 15, FOV: 20-30 cm.Contrast medium injectionCM: Type: Gd-DTPA.• Dose: 0.2 mmol/ kg BW. • Rate: 5ml/s followed by 20ml saline.Time: Starting time: after 8 sec. • Time between...
Results
The mean DSC% value of pharyngeal squamous cell carcinoma was 46.78%.There was significant different in the mean DSC% between non and well differentiated tumors (P<0.003).Table I: the DSC% of pharyngeal cancer.DSC%P valueNode (N):PresentAbsent49.5±4.636.3±4.90.001Tumor volume:Less than 20 (n=16)20-60 (n=30)More than 60 (n=2535.1±3.242.2±3.449.6±4.60.002Pathologic types:Type IType IType I47.5±4.644.9±3.445.9±4.80.193Pathologic grade:Well differentiatedPoorly differentiated39.5±3.549.5±3.70.003The DSC% of squamous cell carcinoma correlated with the size of tumor (P<0.002), associated lymph nodes (P<0.003) and tumor grade (P<0.04).
Conclusion
Dynamic susceptibility contrast percentage (DSC%) of head and neck tumor is a new prognostic parameter that correlated well with morphologic and histologic prognostic parameters.
References
Abdel Razek A, Elserogy L, Soliman N, Nada N. Dynamic Susceptibility Contrast Perfusion MR Imaging in Distinguishing Malignant from Benign Head and Neck Tumors: A Pilot study. European Journal of Radiology (EJR) 2009.Cha S, Knopp E, Johnson G, Wetzel S, Litt A, Zagzag D. Intracranial Mass Lesions: Dynamic Contrast-enhanced Susceptibility-weighted Echo-planar Perfusion MR imaging. Radiology 2002; 223:11–29Sugahara T, Korogi Y, Shigematsu Y, et al. Value of dynamic susceptibility contrast magnetic resonance imaging in the evaluation of intracranial tumors. Top Magn Reson Imaging 1999; 10:114–24Michaely H,...
Personal Information
Prof Dr Ahmed Abdel Khalek Abdel RazekProfessor of diagnostic radiologyMansoura faculty of
[email protected]
