There is conflicting opinion whether the CIN rate following IV contrast administration differs from IA administration and there may be also differences in CIN rates among various types of contrast media. The purpose of this report was to compare incidence of CIN between IV administration of iodixanol (IOCM) for contrast-enhanced computed tomography (CTA) and IA administration of iodixanol or low osmolar contrast media (LOCM) for IA digital subtraction angiography (DSA) in the same population of patients with suspected peripheral arterial occlusive disease (PAOD). The research...

Study Design: Patients with suspected PAOD underwent CTA with IV iodixanol. After a washout of 3 to 14 days, IA DSA was performed with the contrast agent chosen and administered according to the clinical practice standards at each site (Figure 1). Serum creatinine (SCr) was measured pre-procedure and 24 ± 4 hours after the procedure in each phase. Statistical Analysis: CIN was defined as a SCr increase ≥25% from baseline after 24 hours. The population included in analysis was patients with SCr values at both...

A total of 265 patients underwent CTA with IV iodixanol and had complete SCr measurements. A total of 253 of these patients underwent IA DSA with either iodixanol or LOCM administration (3 had both) and had complete SCr measurements. Of these, 148 (58.5%) received iodixanol and 105 (41.5%) received LOCM (iopamidol, 92; ioversol, 8; iohexol, 3; iopromide 2). Four of the 148 patients who received iodixanol and 2 of the 105 patients who received LOCM and had complete SCr measurements in the DSA phase did...

The incidence of CIN following CTA with IV iodixanol (320 mg I/mL) was not statistically different from that following DSA with IA administration of various contrastmedia to patients with PAOD and relatively normal renal function.