Signal Transducer and Activator of Transcription 3 Activation Promotes Invasive Growth of Colon Carcinomas through Matrix Metal loproteinase Induction
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Keywords
Colorectal carcinoma
invasiveness
STAT3
matrix metalloproteinases
gene regulation
Abbreviations
c.a.
constitutively active
CRC
colorectal carcinoma
d.n.
dominant negative
EMSA
electrophoretic mobility shift assay
IL
interleukin
MMP
matrix metalloproteinase
JAK
janus kinase
STAT
signal transducer and activator of transcription
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Part of this work was funded by the Interdisziplinares Zentrum fur Klinische Forschung—IZKF Jena, Project B 307-01035.
Copyright © 2007 Neoplasia Press, Inc. Published by Elsevier Inc.