Researchers have already attributed a certain amount of variability and “drift” in an individual's handwriting pattern to mental workload, but this phenomenon has not been explored adequately. Especially, there still lacks an automated method for accurately predicting mental workload using handwriting features. To solve the problem, we first conducted an experiment to collect handwriting data under different mental workload conditions. Then, a predictive model (called SVM-GA) on two-level handwriting features (i.e., sentence- and stroke-level) was created by combining support vector machines and genetic algorithms. The results show that (1) the SVM-GA model can differentiate three mental workload conditions with accuracy of 87.36% and 82.34% for the child and adult data sets, respectively and (2) children demonstrate different changes in handwriting features from adults when experiencing mental workload.