2005 Volume 30 Issue 4 Pages 409-413
Following a recent report of unexpectedly high affinity of 5-azidoimidacloprid to insect nicotinic acetylcholine receptor, derivatives with four halogen atoms and cyano and nitro were prepared, and the insecticidal effect was evaluated in American cockroaches by injection alone and with synergists, piperonyl butoxide and propargyl propyl benzenephosphonate. The log (1/MLD) value, the minimal lethal dose in mol, was 8.96 for imidacloprid, and 8.82 for the fluoro derivative. The other derivatives were less active. Synergists enhanced the activity of all compounds. The log (1/MLD) value for 5-azidoimidacloprid, 7.37 without or 8.18 with synergists, was not striking in this experiment. © Pesticide Science Society of Japan
