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A simple and cost-effective synthesis of graphene oxide stabilized glucose-capped copper oxide nanoparticles and its antibacterial properties

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Abstract

A simple and cost-effective approach has been used to synthesize biocompatible nanocomposites of graphene oxide, glucose and copper oxide. Basically, three types of nanocomposites (i.e., Glucose-capped copper oxide nanoparticles, GO stabilized copper oxide nanoparticles and GO stabilized glucose-capped copper oxide nanoparticles) are synthesized at 35, 75, and 100°C. All the nanocomposites are characterized for their physical properties and studied for their antibacterial properties. Antibacterial testing against laboratory strains of Escherichia coli and Bacillus anthracis shows that all the nanocomposites synthesized at 35°C possess better antibacterial activities compared to other nanocomposites and GO. In this study, the order of antibacterial activity for synthesized nanocomposites observed is Cu/Glu/GO > Cu/Glu > Cu/GO, suggesting that the Cu/Glu/GO possess comparatively significant antibacterial properties owing to the synergistic effect of copper, glucose and GO. However, it should be further explored to be an alternative antibacterial agent to overcome antimicrobial resistance in near future.

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Abbreviations

AMR:

Antimicrobial resistance

Cu/Glu/GO:

GO stabilized glucose-capped copper oxide nanoparticles

Cu/Glu:

Glucose-capped copper oxide nanoparticles

Cu/GO:

GO stabilized copper oxide nanoparticles

Cu:

Copper

Cu2O:

Cuprous oxide

CuO:

Cupric oxide

Glu:

Glucose

GO:

Graphene oxide

NaOH:

Sodium hydroxide

rGO:

Reduced graphene oxide

ROS:

Reactive oxygen species

SAED:

Selected area electron diffraction

TEM:

Transmission electron microscopy

XRD:

X-ray diffraction

ZOI:

Zone of Inhibition

SD:

Standard deviation

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Acknowledgments

AS is thankful to Advanced Instrumentation Research Facility, Jawaharlal Nehru University, and New Delhi, India for their XRD, TEM, and Raman facilities. AS and HRK acknowledge the facilities and support provided by the School of Biotechnology, Jawaharlal Nehru University, New Delhi.

Funding

The work of AS was supported by University Grant Commission (UGC), Grant Number F.15-1/2016-17/PDFWM-2015-17-UTT-33566 (SA-II). This work was supported by UGC BSR Research Start-Up Grant, Grant Number F.30–473/2019(BSR).

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Authors and Affiliations

  1. School of Biotechnology, Jawaharlal Nehru University, New Delhi, 110067, India

    Anu Singh, Akanksha Gautam, Nidhi Chauhan, Vanshika Dureja, Shivani Kaushik, Sugandha Kashyap & Hemant R. Kushwaha

  2. Samvetan Society for Social and Scientific Research, Dehradun, Uttarakhand, 248001, India

    Nidhi Chauhan & Himanki Dabral

  3. Academy of Scientific and Innovative Research (AcSIR), CSIR-National Physical Laboratory (NPL), Dr. K. S. Krishnan Road, New Delhi, 110012, India

    Shilpi Verma

  4. Department of Genetics and Plant Breeding, School of Agricultural Sciences, Shri Guru Ram Rai University, Patel Nagar, Dehradun, Uttarakhand, 248001, India

    Himanki Dabral

  5. Department of Chemistry, Shyam Lal College, University of Delhi, Delhi, 110032, India

    Arkaja Goswami

  6. CSIR-National Physical Laboratory (NPL), Dr. K. S. Krishnan Road, New Delhi, 110012, India

    Surinder P. Singh

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Contributions

AS and SK (Sugandha Kashyap) together planned and designed the research work. AG (Akanksha Gautam), NC, VD, and SK (Shivani Kaushik) performed experimental work and analyzed the results. AS, AG (Akanksha Gautam), SV and HD Writing-Original Draft Preparation. AS and HRK reviewing, and final editing the manuscript. HRK, AG (Arkaja Goswami) and SP read and approved the final manuscript.

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Correspondence to Hemant R. Kushwaha.

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Singh, A., Gautam, A., Chauhan, N. et al. A simple and cost-effective synthesis of graphene oxide stabilized glucose-capped copper oxide nanoparticles and its antibacterial properties. Journal of Materials Research 38, 3980–3994 (2023). https://doi.org/10.1557/s43578-023-01115-5

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