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Metal–ligand-based thixotropic self-healing poly (vinyl alcohol) metallohydrogels: Their application in pH-responsive drug release and selective adsorption of dyes

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Abstract

This work reports in situ fabrication of biocompatible metallohydrogels composed of polyvinyl alcohol (PVA) polymer crosslinked via coordination complexation between polymeric O− and Mn+ (Mn+ = Ni2+, Fe3+ and Cu2+ ions) at room temperature. The obtained metallohydrogels exhibited the remarkable thixotropic and rapid self-healing properties. Among the three metallogels, Cu-PVA hydrogel exhibited high mechanical strength, elasticity, fatigue resistance, and self-healing ability due to stronger bonding followed by Fe-PVA and Ni-PVA metallohydrogels. Furthermore, these metallohydrogels depicted pH-responsive drug release with sustained release at basic pH while a burst release at neutral and acidic pH values. In addition, they exhibited selective adsorption towards anionic dyes in a mixture of cationic, anionic, and neutral dyes, thereby making them suitable candidates as dye separation agents. Hence, the as-prepared metallohydrogels are promising and potential materials with biocompatibility, high mechanical strength, elasticity, thixotropy, and quick self-healing properties for biomedical and environmental remediation fields.

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Acknowledgments

SA acknowledges the financial support from the Council of Scientific and Industrial Research, HRDG, India under File No (09/251(0059)/2015-EMR-1) as SRF. AAD acknowledges the Department of Science and Technology (DST) Govt. of India for providing funds under the FIST scheme to the Department of the Chemistry University of Kashmir for procuring various instruments.

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Authors and Affiliations

  1. Soft Matter Research Group, Department of Chemistry, University of Kashmir, Hazratbal, Srinagar, J&K, 190006, India

    Saima Afzal, Masrat Maswal, Mohd Sajid Lone, Uzma Ashraf & Aijaz Ahmad Dar

  2. Department of Chemistry, Govt. Degree College, Pulwama, J&K, 192301, India

    Masrat Maswal

  3. Department of Chemistry, Amar Singh College, Gogji Bagh, Srinagar, J&K, 190008, India

    Uzma Ashraf

  4. Department of Biotechnology, University of Kashmir, Hazratbal, Srinagar, J&K, 190006, India

    Umar Mushtaq

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  1. Saima Afzal
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Correspondence to Aijaz Ahmad Dar.

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Afzal, S., Maswal, M., Lone, M.S. et al. Metal–ligand-based thixotropic self-healing poly (vinyl alcohol) metallohydrogels: Their application in pH-responsive drug release and selective adsorption of dyes. Journal of Materials Research 36, 3293–3308 (2021). https://doi.org/10.1557/s43578-021-00361-9

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