Abstract
The present work presents the synthesis, characterization and evaluation of the biocompatibility and ability to dissolve and chemically protect the anticancer drug doxorubicin (DOXO) of two polyethylene oxide-polystyrene oxide triblock copolymers, EO33SO13EO33 and EO38SO10EO38, where EO and SO denote the ethylene oxide and styrene oxide blocks, respectively. Block copolymer length and SO/EO ratio were selected with the objective of ensuring an optimal compromise between chain solubility, micelle formation ability and core size for enhanced drug solubilization. The temporal stability of the drug-loaded micelles and drug release profile were also analyzed as well as their efficacy as an antitumoral polymeric formulation in vitro by using a multidrug resistant ovarian tumor cell line (NCI-ADR-RES), with the special aim of analyzing the possible capability of both copolymers as potential P-glycoprotein efflux (P-gp) pump inhibitors to enhance DOXO accumulation in this cell line.
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Acknowledgments
The authors thank Ministerio de Ciencia e Innovation (MICINN) for research project MAT 2010-17336, Xunta de Galicia for research project INCITE09206020PR and European Regional Development Funds (research project 2010/50), and Fundacion Ramon Areces for additional financial support. S.B thanks RyC (MEC, Spain) program.
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Cambón, A., Rey-Rico, A., Barbosa, S. et al. Polyethylene Oxide-Polystyrene Oxide Triblock Copolymers as Biological-Responsive Nanocarriers.. MRS Online Proceedings Library 1468, 7–12 (2012). https://doi.org/10.1557/opl.2012.1447
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DOI: https://doi.org/10.1557/opl.2012.1447