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Controlled loading of paramagnetic gadolinium oxide nanoplates in PMAO-g-PEG as effective T1-weighted MRI contrast agents

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Abstract

Plate-shaped Gd2O3 nanoclusters (GNCs) with well-controlled loading were fabricated by using amphiphilic poly(maleic anhydride-alt-1-octadecene) (PMAO) grafted with PEG as nanogel. The hydrodynamic size of the obtained GNCs was well controlled to <260 nm under appropriate emulsion process conditions and they showed excellent long-term dispersibility in phosphate buffer saline. MRI measurements clearly indicated the substantial improvement in T1 effect of the nanoclusters as compared with the individual Gd2O3 nanoplates. The obtained GNCs possessed a high r1 value of 7.948 s−1mM−1 [Gd], which is 2.23 times higher than that of the commercial product Gd-DOTA, and low r2/r1 of 1.04. In vitro test of the obtained GNCs was demonstrated in NIH/3T3 cell lines, and clear T1-weighted images were obtained. Thus, the PMAO-g-PEG assisted GNCs were potentially useful for T1-weighted MRI contrast agents.

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ACKNOWLEDGMENTS

This work is supported by the MOE’s ARF Tier 1 funding WBS R-284-000-102-112 (National University of Singapore, Singapore).

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  1. Department of Materials Science and Engineering, Faculty of Engineering, National University of Singapore (NUS), Singapore, 117574, Singapore

    Jiaquan Yuan, Erwin Peng & Jun Min Xue

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  1. Jiaquan Yuan
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  2. Erwin Peng
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  3. Jun Min Xue
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Correspondence to Jun Min Xue.

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Yuan, J., Peng, E. & Xue, J.M. Controlled loading of paramagnetic gadolinium oxide nanoplates in PMAO-g-PEG as effective T1-weighted MRI contrast agents. Journal of Materials Research 29, 1626–1634 (2014). https://doi.org/10.1557/jmr.2014.185

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