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Synthesis of novel core–shell structural AuNR@MCM-41 for infrared light-driven release of drug

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Abstract

The hexagonal mesoporous silica MCM-41 nanospheres with Au nanorods (AuNRs) as core have been synthesized via a modified Stöber method by a process of hydration and condensation of tetraethoxysilane in a water–ethanol mixture. The AuNR@MCM-41 nanocomposites combine the photothermal characteristic with the mesopore of MCM-41 in one body. We utilized these core–shell materials for ibuprofen encapsulation and release in the simulated body fluid (pH 7.4) for the first time. The results certificated AuNR@MCM-41 nanocomposites as novel dual-functional materials could realize the light-driven release of drug due to the photothermal effect of the AuNRs. Such novel nanomaterials offer a new way for cancer treatment which combine hyperthermia with the chemotherapeutic drugs by synergistic effect.

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Acknowledgments

The authors are thankful to the National Science Fund for Distinguished Young Scholars of China (Grant No. 60925018) and the National Natural Science Foundation of China (Grant Nos. 20971051 and 51002062).

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Authors and Affiliations

  1. State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun, 130012, People’s Republic of China

    Liping Xie, Biao Dong, Zhenlong Jiang, Yu Wang, Tong Liu & Xue Bai

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  1. Liping Xie
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  2. Biao Dong
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  3. Zhenlong Jiang
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  4. Yu Wang
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  5. Tong Liu
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Correspondence to Biao Dong.

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Xie, L., Dong, B., Jiang, Z. et al. Synthesis of novel core–shell structural AuNR@MCM-41 for infrared light-driven release of drug. Journal of Materials Research 26, 2414–2419 (2011). https://doi.org/10.1557/jmr.2011.292

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  • DOI: https://doi.org/10.1557/jmr.2011.292

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