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Green synthesis of chitosan capped silver nanoparticles and their antimicrobial activity

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Abstract

Chitosan is a polymeric compound with functional groups which enable surface binding to nanoparticles and antibacterial activity. The antimicrobial activity was studied using silver nanoparticles with varied concentrations of chitosan. The nanoparticles were synthesized through a simple and environmentally friendly method at room temperature. Spherical particles with average sizes between 2 and 6 nm were obtained and their crystallinity showed a face-centered cubic phase. The evidence of chitosan presence on the nanoparticle surface was confirmed by the characteristic diffraction peak of chitosan and by FTIR spectra where the bonding of amine group could be depicted. The chitosan-capped silver nanoparticles showed good antibacterial and antifungal activities with MIC values between 0.20 and 1.5 mg.mL-1 compared to those obtained from most of references (up to 6.25 mg.mL-1) on the selected gram-positive (Staphylococcus aureus, Enterococcus faecalis), gram-negative (Klebsiella pneumoniae, Pseudomonas aeruginosa ) bacteria and fungi (Candida albicans, Cryptococcus neoformans).

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Authors and Affiliations

  1. Department of Chemistry, Vaal University of Technology, Private Bag X021, Vanderbijlpark, 1900, South Africa

    Zondi Nate, Makwena Justice Moloto & Pierre Kalenga Mubiayi

  2. Department of Chemistry and Physics, University of Kwazulu-Natal, Private Bag X01, Pietermaritzburg, 3209, South Africa

    Precious Nokwethemba Sibiya

Authors
  1. Zondi Nate
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  2. Makwena Justice Moloto
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  3. Pierre Kalenga Mubiayi
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  4. Precious Nokwethemba Sibiya
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Correspondence to Makwena Justice Moloto.

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Nate, Z., Moloto, M.J., Mubiayi, P.K. et al. Green synthesis of chitosan capped silver nanoparticles and their antimicrobial activity. MRS Advances 3, 2505–2517 (2018). https://doi.org/10.1557/adv.2018.368

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