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Optical Manipulation of Objects in Microfluidic Devices

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Abstract

In this paper, we present object manipulation methodologies in microfluidic devices based on object-photon interactions. Devices were fabricated by polydimethylsiloxane (PDMS) elastomer molding of channel structures over photolithographically defined patterns using a thick negative photoresist. Inorganic objects including polystyrene spheres and organic objects including live cells were transferred into fluidic channels using a syringe pump. The objects were trapped and manipulated within the fluidic channels using optical tweezers formed by VCSEL arrays, with only a few mW of optical power. We have also shown that it is possible to manipulate multiple objects as a whole assemble by using an optically-trapped particle as a handle, or an “optical handle”. Optical manipulation will have applications in biomedical devices for drug discovery, cytometry and cell biology research.

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Authors and Affiliations

  1. Electrical Engineering Department, University of California, San Diego, USA

    Erhan Ata, Aaron L. Birkbeck, Richard Flynn, Mark Wang & Sadik Esener

  2. Electrical Engineering Department, University of California, Riverside, USA

    Mihrimah Ozkan

  3. Mechanical Engineering Department, University of California, Riverside, USA

    Cengiz S. Ozkan

Authors
  1. Erhan Ata
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  2. Aaron L. Birkbeck
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  3. Mihrimah Ozkan
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  4. Cengiz S. Ozkan
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  5. Richard Flynn
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  6. Mark Wang
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  7. Sadik Esener
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Ata, E., Birkbeck, A.L., Ozkan, M. et al. Optical Manipulation of Objects in Microfluidic Devices. MRS Online Proceedings Library 729, 16 (2002). https://doi.org/10.1557/PROC-729-U1.6

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  • DOI: https://doi.org/10.1557/PROC-729-U1.6

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