Abstract
Vitamin E TPGS was found to be an effective structure-directing agent for the preparation of both hexagonal all silica DAM-1 and the alumina analog, Al-DAM-1. These free flowing powders offer many advantages in the handling and oral delivery of the sticky vitamin E TPGS. Upon exposure to simulated gastric fluid, the Al-DAM-1 host molecular sieve is dissolved releasing the vitamin E TPGS. As much as 0.6 grams of vitamin E TPGS can be immobilized into 1 gram of Al-DAM-1. Vitamin E TPGS also templates highly ordered mesoporous DAM-1 with tunable morphologies such as hexagons (various lengths), gyroids, rods, spheres and discoids depending upon the temperature and gel composition. Characterization of these composites as well as a preliminary evaluation of Al-DAM-1 as an oral drug delivery system under physiological conditions is presented.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
K. J. Balkus, Jr., L. Washmon-Kriel, J. E. Lucas Submitted.
K. J. Balkus, Jr., D. Coutinho, J. E. Lucas, L. Washmon-Kriel, MRS Symposium Proc. 628, (in press).
J.F. Diaz and K.J. Balkus Jr., J. Mol. Catal. B: Enzymatic, 2, 115 (1996).
M.E. Gimon-Kinsel, V.L. Jimenez, L. Washmon and K.J. Balkus, Jr., Stud. Surf. Sci. Catal, 117, 373 (1998).
L. Washmon-Kriel, V.L. Jimenez and K.J. Balkus, Jr., J. Mol. Catal. B: Enzymatic, 10, 453 (2000).
R. Casani in Kirk-Othmer Encyclopedia of Chemical Technology, Vol. 25, 4th ed., R.E. Kirk, D.F. Othmer, J.I. Kroschwitz, M. Howe-Grant (Eds.), (John Wiley & Sons: New York, 1998), p 256.
H.K. Hobbs, J.E. Huffaker, E.M. Taggart and A.M. Papas, US Patent 5,234,659, (1993).
A.M. Papas, The Vitamin E Factor, (Harper Collins Publishers, 1999).
M.W. Dicks, Vitamin E Content of Foods and Feeds for Human and Animal Consumption, Bulletin 435, (University of Wyoming: Laramie, 1965).
E. Shute, The Heart and Vitamin E, Shute (Found. for Med. Res.: London, 1963).
Roche Primer, Vitamin E for Farm Animals, (Hoffman-La Roche, Nutley, New Jersey, 1965).
B. Beaver, J. Chem. Ed., 76, 1108 (1999).
Eastman Chemical Report Publication EFC-226A, October (1998).
R.J. Sokol, N. Butler-Simon and C. Conner, Gastroenterology, 104, 1727 (1993).
M.G. Traber, T.D. Schiano, A.C. Steephen, J. Kayden and M. Shike, Am. J. Clin. Nutr. 59, 1270 (1994).
M.G. Traber, C.A. Thellman, M.J. Rindler and H.J. Kayden, Am. J. Clin. Nutr. 48, 605 (1988).
K.J. Balkus, Jr., and A. Scott, Micropor. Mesopor. Mater., 38, 97 (2000).
S. M. Yang, H. Yang, N. Coombs, I. Sokolov, C. T. Kresge, G. A. Ozin, Adv. Mat. 11, 52 (1999).
H. Yang, G. Vovk, N. Coombs, I. Sokolov, G. A. Ozin, J. Mat. Chem, 8, 743 (1998).
H. Yang, N. Coombs, G. A. Ozin, Nature, 386, 692 (1997).
C. Y. Mou, H. P. Lin, Pure Appl. Chem., 72, 137, (2000).
D. Zhao, J. Sun, Q. Li, G. D. Stucky, Chem. Mat., 12, 275 (2000).
S. Yang, I. Sokolov, N. Coombs, C.T. Kresge and G.A. Ozin, Adv. Mater., 11, 1427 (1999).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Coutinho, D., Ma, Y. & Balkus, K.J. Preparation and Charaterization of DAM-1 type Materials. MRS Online Proceedings Library 662, 65 (2000). https://doi.org/10.1557/PROC-662-NN6.5
Published:
DOI: https://doi.org/10.1557/PROC-662-NN6.5