Skip to main content
SpringerLink
Log in

Using Indentation and Intra-Vascular Ultrasound to Measure Arterial Response

  • Published:
MRS Online Proceedings Library Aims and scope

Abstract

Two alternatives to standard tensile testing of arteries are discussed. The first involves inflation of arteries and simultaneous measurement of radial displacement with intra-vascular ultrasound (IVUS). The second involves the measurement of load versus displacement during micro-indentation of the intimal surface. The IVUS technique is used to study the nonlinear stiffening of porcine coronaries during inflation and, ultimately, it may provide a method to determine mechanical properties in vivo. Processing of the IVUS data relies on accurate determination of the luminal/intimal and medial/advential boundaries during inflation. The microindentation technique is used to study the effect of loading rate on tissue stiffness, recovery, and internal dissipation. Ultimately, this technique may provide a method to measure local mechanical properties in the vicinity of an atherosclerotic plaque, for example. Accurate determination of the initial contact point between the indenter and intima is required, however. The techniques appear to successfully capture significant, nonlinear, time-dependent properties of arterial tissue.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. V. Fuster, B. Stein, J.A. Ambrose, L. Badimon, J.J. Badimon, and J.H. Chesebro, Circ. 82 (supp II), pp. II–47 (1990).

    Google Scholar 

  2. P. Constantinides, Am. J. Cardiol. 66, pp. 37G–40G (1990).

    Article  CAS  Google Scholar 

  3. A.I. Veress, D.G. Vince, P.M. Anderson, J.F. Cornhill, E.E. Herderick, J.D. Klingensmith, B.D. Kuban, N.L. Greenberg, and J.D. Thomas, Z Kardiol. 89(Suppl. 2), pp. 92–100 (2000).

    Article  Google Scholar 

  4. D.J. Patel, J.S. Janicki, and T.E. Carew, Circ. Res. 25, pp. 765–779 (1969).

    Article  CAS  Google Scholar 

  5. H.W. Weisacker, H. Lambert, and K. Pacale, J. Biomech 16, pp. 703–715 (1981).

    Article  Google Scholar 

  6. P.B. Dobrin, J. Biomech. 19(5), pp. 351–358 (1986).

    Article  CAS  Google Scholar 

  7. R.H. Cox, Am. J. Physiol. 235(5), pp. H533–H541 (1978).

    Google Scholar 

  8. P.B. Dobrin, J. Biomech. 19(5), pp. 351–358 (1986).

    Article  CAS  Google Scholar 

  9. M. Anliker, W.E. Moritz, and E. Ogden, J. Biomech. 1, pp. 235–246 (1968).

    Article  CAS  Google Scholar 

  10. E.M.L. Attinger, Circ. Res. 22, pp. 829–840 (1968).

    Article  CAS  Google Scholar 

  11. R.H. Cox, J. Biomech. 8, pp. 293–300 (1975).

    Article  CAS  Google Scholar 

  12. P.B. Dobrin and J.M. Doyle, Circ. Res. 27, pp. 105–119 (1970).

    Article  CAS  Google Scholar 

  13. A.G. Hudentz and E. Monos, Acta Phys. Sci. Hungaricai 75, pp. 111–122 (1981).

    Google Scholar 

  14. P.B. Dobrin and Mrkvicka, J. Hypertension 10(Suppl. 6), pp. S7–S10 (1992).

    Article  CAS  Google Scholar 

  15. J. Ophir, E.I. Cespedes, H. Ponnekanti, Y. Yazki, and X. Li, Imaging 13(2), pp. 111–34 (1991).

    CAS  Google Scholar 

  16. C.L. deKorte, H.A. Woutman, A.F. vander Steen, G. Pasterkamp, and E.I. Cespedes, Ultrasonics 38(1–8), pp. 387–90 (2000).

    Article  CAS  Google Scholar 

  17. J.D. Klingensmith, R. Shekhar, and D.G. Vince, IEEE Trans. Med. Imaging 19(10), pp. 1–17 (2000).

    Google Scholar 

  18. B.S. Gow and C.D. Hadfield, Circ. Res. 45, pp. 588–594 (1979).

    Article  CAS  Google Scholar 

  19. K.L. Johnson, Contact Mechanics, Cambridge University Press, New York 1987.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Materials Science and Engineering, Ohio State University, 2041 College Rd., Columbus, OH, 43210-1179, USA

    P. M. Anderson

  2. Biomedical Engineering, Ohio State University, Columbus, OH, 43210-1002, USA

    E. N. Glaser & E. E. Herderick

  3. Medical Imaging Research Lab, University of Utah, Salt Lake City, UT, 84108-1218, USA

    A. I. Veress

  4. Oak Ridge National Laboratory, P.O. Box 2008, Oak Ridge, TN, 37831-6116, USA

    G. M. Pharr

  5. Biomedical Engineering, The Cleveland Clinic, Cleveland, OH, 44195-0001, USA

    D. G. Vince & J. F. Cornhill

Authors
  1. P. M. Anderson
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. N. Glaser
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. I. Veress
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. G. M. Pharr
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. D. G. Vince
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. J. F. Cornhill
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. E. E. Herderick
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to P. M. Anderson.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Anderson, P.M., Glaser, E.N., Veress, A.I. et al. Using Indentation and Intra-Vascular Ultrasound to Measure Arterial Response. MRS Online Proceedings Library 662, 24 (2000). https://doi.org/10.1557/PROC-662-MM2.4

Download citation

  • Published:

  • DOI: https://doi.org/10.1557/PROC-662-MM2.4

Search

Navigation