Skip to main content
Log in

Novel Collagen Based Material for Local Drug Delivery Systems

  • Published:
MRS Online Proceedings Library Aims and scope

Abstract

In a search for new drug delivery matrix, the synthesis of a novel collagen material based on tiopronin protected gold clusters (MPC) as a crosslinking agent is proposed. The structure of collagen matrix modified with MPC is studied using transmission electron microscope. The thermal properties are examined with differential scanning calorimetry. To assess the biocompatibility of the matrix, the cytotoxicity assays are conducted.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. D.G. Wallace, J. Rosenblatt, Adv. Drug Delivery Rev. 55, 1631–1549 (2003)

    Article  CAS  Google Scholar 

  2. A. Sano, M. Maeda, S. Nagahara, T. Ochiya, K. Honma, H. Itoh, T. Miyata, K. Fujioka, Adv. Drug Delivery Rev. 55, 1651–1677 (2003)

    Article  CAS  Google Scholar 

  3. J.F. Bateman, S. Lamande and J.A.M. Ramshaw, Collagen superfamily. In: W.D. Comper Ed., Extracellular Matrix: Vol. 2, Molecular Components and Interactions, Harwood Academic Publishers, Amsterdam, pp. 22–67 (1995)

    Google Scholar 

  4. Z. Ruszczak, W. Friess, Drug Delivery Rev. 55, 1679–1698 (2003)

    Article  CAS  Google Scholar 

  5. H.O. Ho, C.W. Lin, M.T. Sheu, , J. Control. Release 77, 97–105 (2001)

    Article  CAS  Google Scholar 

  6. T.J. Housley, M.L. Tanzer, E. Henson, P.M. Gallop, Biochem. Biophys. Res. Commun. 67, 824–829 (1975)

    Article  CAS  Google Scholar 

  7. X. Duan, H. Sheardown, J. Biomed. Mater.Res. A, 75, 510–518 (2005)

    Article  CAS  Google Scholar 

  8. M. Brust, M. Walker, D. Bethell, D.J. Schiffrin, R. Whyman, J. Chem. Soc. Chem. Commun. 801–802 (1994)

  9. A.C. Templeton, S. Chen, S.M. Gross, R.W. Murray, Langmuir, 15, 66–76 (1998)

    Article  Google Scholar 

  10. H.O. Ho, L.H. Lin, M.T. Sheu, J. Control. Release 44, 103–112 (1997)

    Article  CAS  Google Scholar 

  11. D. Giron, J. Therm. Anal. Cal. 56, 1285–1304 (1999)

    Article  CAS  Google Scholar 

  12. G.M. Mrevlishvili, D.W. Svintradze, Int. J. Biol. Macromol. 35, 243–245 (2005)

    Article  CAS  Google Scholar 

  13. D.L. Wise, Biomaterials and bioengineering handbook, Marcel Dekker, NY, (2000)

    Google Scholar 

  14. D.L. Spector, R.D. Goldman, L.A. Leinwand, Cells. A laboratory manual. Vol I: Culture and biochemical analysis of cells, Cold Spring Harbor Laboratory Press, (1998).

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Castaneda, L., Pluskat, S., Ky, D. et al. Novel Collagen Based Material for Local Drug Delivery Systems. MRS Online Proceedings Library 1008, 908 (2007). https://doi.org/10.1557/PROC-1008-T09-08

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1557/PROC-1008-T09-08

Navigation