Assessment of Factors Influencing Adherence to Antidiabetic Drugs among Patients with Type 2 Diabetes Mellitus at a Tertiary Care Hospital in India
Abstract
Diabetes mellitus is a chronic endocrine disorder that requires long-term treatment. Non-adherence to anti-diabetic drugs is common and associated with poor outcomes. Non-adherence leads to complications, higher incidence of hospital admissions and imposes economic burden. Hence, the present study was undertaken to measure adherence to anti-diabetic medication and factors contributing to it. This cross-sectional study was conducted among patients on anti-diabetic medication after taking their informed consent in a tertiary care hospital in India. Each patient’s demographic, clinical, and treatment data along with the adherence to treatment has been assessed during a personal interview with each patient using Medication Adherence Report Scale (MARS-5). Factors contributing to medication adherence was assessed using chi-square test. A total of 250 patients were recruited in the study. The mean age was 54 years and non-adherence to anti-diabetic medications was 21.6%. Univariate Analysis showed that marital status, education status, good glycemic control, illness >5years had a statistically significant association (p=<0.05) with self-reported adherence to anti-diabetic medication.
Keywords
Full Text:
PDFReferences
American Diabetes Association. Improving care and promoting health in populations: Standards of Medical Care in Diabetes-2020. Diabetes Care. 2020 jan;43(Suppl.1): S7–S13.
Saeedi P, Petersohn I, Salpea P, Malanda B, Karuranga S, Unwin N et al. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from IDF Diabetes Atlas, 9th edition. Diabetes Research and Clinical Practice. 2019 Nov;157:107843
Arifulla M, John LJ, Sreedharan J, Muttappallymyalil J, Basha SA. Patients’ Adherence to Anti-Diabetic Medications in a Hospital at Ajman, UAE. Malaysian Journal of Medical Science. Jan-Feb 2014; 21(1): 44-49
Sapkota S, Brien J-a, Greenfield J, Aslani P. A Systematic Review of Interventions Addressing Adherence to Anti-Diabetic Medications in Patients with Type 2 Diabetes-Impact on Adherence. PLoS One. feb2015;10(2):e0118296. doi:10.1371/journal.pone.0118296
Venkatesan M, Dongre AR, Ganapathy K. A Community-Based Study on Diabetes Medication Nonadherence and its Risk Factors in Rural Tamil Nadu. Indian Journal of Community Medicine. 2018 Apr-Jun;43(2):72-76
Kavitha S, Nalini GK, Suresh RM, Sahana GN, Deepak P, Nagaral JV. Treatment adherence and factors contributing to non adherence among type 2 diabetes mellitus patients in a tertiary care hospital: a cross sectional study. International Journal of Basic Clinical Pharmacology. 2017;6:689-94.
Shrestha SS, Shakya R, Karmacharya BM, Thapa P. Medication adherence to oral hypoglycemic agents amongst type II diabetic patients and their clinical outcomes with special reference to fasting blood glucose and glycosylated hemoglobin levels. Kathmandu University Medical Journal.2013;11:226-32.
Shaimol T, Biji CR, Anilasree BP, Jayakrishnan SS, Babu G. Medication Adherence to Oral Hypoglycemic Agents in Type 2 Diabetic Patients. Journal of Pharmaceutical Research and Clinical Practice, April-June 2014; 4(2):8-12
Vermeire E, Hearnshaw H, Van Royen P, Denekens J. Patient adherence to treatment: three decades of research. A comprehensive review. Journal of Clinical Pharmology Therapy. 2001;26(5):331–342.
Skinner TC, John M, Hampson SE. Social support and personal models of diabetes as predictors of self-care and well-being: a longitudinal study of adolescents with diabetes. Journal of Pediatric Psychology. 2000 Jun;25(4):257-67
DiMatteo MR. Variations in patients’ adherence to medical recommendations: quantitative review of 50 years of research. Medical Care 2004; 42: 200–9.
Bruce SP, Acheampong F, Kretchy I. Adherence to oral anti-diabetic drugs among patients attending a Ghanaian teaching hospital. Pharmacy Practice. 2015 Jan-Mar;13(1):533.
Lemay J, Waheedi M, Al-Sharqawi S, Bayoud T. Medication adherence in chronic illness: do beliefs about medications play a role?. Patient Prefer Adherence.2018:12 1687–169
Jin J, Sklar GE, Sen Oh VM, Chuen Li S. Factors affecting therapeutic compliance: A review from the patient’s perspective. Therapeutic and Clinical Risk Management. 2008;4(1):269-86.
Abebaw M, Messele A, Hailu M, Zewdu F. Adherence and Associated Factors towards Antidiabetic Medication among Type II Diabetic Patients on Follow-Up at University of Gondar Hospital, Northwest Ethiopia. Advances In Nursing. 2016: 1-7 Article ID: 8579157
Bagonza J, Rutebemberwa E, Bazeyo W. Adherence to anti-diabetic medication among patients with diabetes in eastern Uganda; a cross sectional study. Biomedical Care Health Services Reseacrh. 2015;15:168
Claxton AJ, Cramer J, Pierce C. A systematic review of the associations between dose regimens and medication compliance. Clinical Therapy. 2001;23:1296–310.
Kirman MS, Rowan-Martin MT, Levin R,Fonseca VA, Schmittdiel JA, Herman WH et al. Determinants of Adherence to Diabetes Medications: Findings From a Large Pharmacy Claims Database. Diabetes Care. 2015; 38:604–609
Balkhi B, Alwhaibi M, Alqahtani N, Alhawassi T, Alshammari TM, Mahmoud M et al. Oral antidiabetic medication adherence and glycaemic control among patients with type 2 diabetes mellitus: a cross-sectional retrospective study in a tertiary hospital in Saudi Arabia. Biomedical Journal Open. 2019;9:e029280.
Lee CS, Tan JHM, Sankari U, Eileen Koh YL, Chuan Tan N. Assessing oral medication adherence among patients with type 2 diabetes mellitus treated with polytherapy in a developed Asian community: a cross sectional study. Biomedical Journal Open. 2017;7:e016317.
Digital Object Identifier
DOI : https://doi.org/10.15416/pcpr.v5i1.26507Dimension Citation Metrics Badge
Refbacks
- There are currently no refbacks.
Pharmacology and Clinical Pharmacy Research is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
Refbacks
- There are currently no refbacks.