Skip to main content
SpringerLink
Log in

Case of B-Cell Lymphoma with Rearrangement of the BCL1, BCL2, BCL6, and c-MYC Genes

  • Case Report
  • Published:
International Journal of Hematology Aims and scope Submit manuscript

Abstract

We managed a peculiar case of lymphoma showing immunohistochemical overexpression of cyclin D1. At initial examination the patient had meningeal lymphomatosis and general lymphadenopathy. Histologic examination of biopsy specimens of inguinal lymph nodes showed tumor cells and vague nodular growth resembling lymphoblasts. The results of flow cytometric analysis were positive for CD10, CD20, CD103, and immunoglobulin G (IgG) and Igκ and were negative for CD5, CD23, and terminal deoxynucleotidyl transferase activity. Results of immunohistochemical analysis of paraffin-embedded specimens were positive for cyclin D1 and Bc12 in the tumor cells. Sixty percent of tumor cells had positive results for MIB1/Ki67. Cytogenetic and molecular studies revealed tumor cells simultaneously had t(14;18)(q32;q21), t(11;22)(q13;q11), t(8;14)(q24;q32), and t(3;14)(q27;q32) with the rearrangement of BCL1, BCL2, BCL6, and c-MYC genes. Lymphadenopathy showed a quick and complete response to doxorubicin-containing systemic chemotherapy with rituximab, but the central nervous system disease progressed and killed the patient.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Solomon E, Borrow J, Goddard AD. Chromosomal aberrations and cancer. Science. 1991;254:1153–1160.

    Article  CAS  PubMed  Google Scholar 

  2. Nakamura S, Yatabe Y, Kuroda H, et al. Immunostaining of PRAD1/cyclin D1 protein as a marker for the diagnosis of mantle cell lymphoma. Leukemia. 1997;11:536–537.

    Article  PubMed  Google Scholar 

  3. Nakamura S, Shiota M, Nakagawa A, et al. Anaplastic large cell lymphoma: a distinct molecular pathologic entity: a reappraisal with special reference to p80 (NPM/ALK) expression. Am J Surg Pathol. 1997;21:1420–1432.

    Article  CAS  PubMed  Google Scholar 

  4. Swerdlow SH, Berger F, Issacson PI, et al. Mantle cell lymphoma. In: Jaffe ES, Harris NL, Stein H, Vardiman JW, eds. Pathology and Genetics: Tumors of Haematopoietic and Lymphoid Tissues— World Health Organization Classification of Tumors. Lyon, France:IARC Press; 2001:168–170.

    Google Scholar 

  5. Takahashi N, Nakai S, Honjo T. Cloning of human immunoglobulin mu gene and comparison with mouse mu genes. Nucleic Acids Res. 1980;8:5983–5991.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  6. Tsujimoto Y, Cossman J, Jaffe E, Croce CM. Involvement of the bcl-2 gene in human follicular lymphoma. Science. 1985;228:1440–1443.

    Article  CAS  PubMed  Google Scholar 

  7. Crescenzi M, Seto M, Herzig GP, Weiss PD, Griffith RC, Korsmeyer SJ. Thermostable DNA polymerase chain amplification of t(14;18) chromosome breakpoints and detection of minimal residual disease. Proc Natl Acad Sci USA. 1988;85:4869–4873.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  8. Bergsagel PL, Chesi M, Nardini E, Brents LA, Kirby SL, Kuehl WM. Promiscuous translocations into immunoglobulin heavy chain switch regions in multiple myeloma. Proc Natl Acad Sci USA. 1996;93:13931–13936.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  9. Miki T, Kawamata N, Arai A, et al. Molecular cloning of the breakpoint for 3q27 translocation in B-cell lymphomas and leukemias. Blood. 1994;83:217–222.

    PubMed  CAS  Google Scholar 

  10. Nomura K, Yoshino T, Nakamura S, et al. Detection of t(11;18) (q21;q21) in marginal zone lymphoma of mucosa-associated lymphocytic tissue type on paraffin-embedded tissue sections by using fluorescence in situ hybridization. Cancer Genet Cytogenet. 2003;140:49–54.

    Article  PubMed  CAS  Google Scholar 

  11. Tsujimoto Y, Jaffe E, Cossman J, Gorham J, Nowell PC, Croce CM. Clustering of breakpoints on chromosome 11 in human B-cell neoplasms with the t(11;14) chromosome translocation. Nature. 1985;315:340–343.

    Article  CAS  PubMed  Google Scholar 

  12. Motokura T, Bloom T, Kim HG, et al. A novel cyclin encoded by a bcl1-linked candidate oncogene. Nature. 1991;350:512–515.

    Article  PubMed  CAS  Google Scholar 

  13. Willis TG, Jadayel DM, Coignet LJ, et al. Rapid molecular cloning of rearrangements of the IGH J locus using long-distance inverse polymerase chain reaction. Blood. 1997;90:2456–2464.

    PubMed  CAS  Google Scholar 

  14. Karsan A, Gascoyne RD, Coupland RW, Shepherd JD, Phillips GL. Combination of t(4;18) and a Burkitt’s type translocation in B-cell malignancies. Leuk Lymphoma. 1993;10:433–441.

    Article  PubMed  CAS  Google Scholar 

  15. Sonoki T, Siebert R, Taniguchi I, Hata H, Dyer MJS, Mitsuya H. Activation of MYC by cytogenetically cryptic chromosome translocation, t(8;17)(q24;q22). Ann Oncol. 2002;13(suppl 2):50.

    Google Scholar 

  16. Komatsu H, Yoshida K, Seto M, et al. Overexpression of PRAD1 in a mantle zone lymphoma patient with a t(11;22)(q13;q11) translocation. Br J Haematol. 1993;85:427–429.

    Article  PubMed  CAS  Google Scholar 

  17. Oinonen R, Franssila K, Elonen E. Central nervous system involvement in patients with mantle cell lymphoma. Ann Hematol. 1999;78:145–149.

    Article  PubMed  CAS  Google Scholar 

  18. Dong HY, Gorczyca W, Liu Z, et al. B-cell lymphomas with coexpression of CD5 and CD10. Am J Clin Pathol. 2003;119:218–230.

    Article  PubMed  Google Scholar 

  19. Dyer MJS. The pathogenetic role of oncogenes deregulated by chromosomal translocation in B-cell malignancies. Int J Hematol. 2003;77:315–320.

    Article  PubMed  CAS  Google Scholar 

  20. Jaeger U, Karth GD, Knapp S, Friedl J, Laczika K, Kusec R. Molecular mechanism of the t(14;18): a model for lymphoid-specific chromosomal translocations. Leuk Lymphoma. 1994;14:197–202.

    Article  PubMed  CAS  Google Scholar 

  21. Tilly H, Rossai A, Stamatoullas A, et al. Prognostic value of chromosomal abnormalities in follicular lymphoma. Blood. 1994;84:1043–1049.

    PubMed  CAS  Google Scholar 

  22. Limpens J, Stad R, Vos C, et al. Lymphoma-associated translocation t(14;18) in blood B cells of normal individuals. Blood. 1995;85:2528–2536.

    PubMed  CAS  Google Scholar 

  23. Hao S, Sanger W, Onciu M, Lai R, Schlette EJ, Medeiros LJ. Mantle cell lymphoma with 8q24 chromosomal abnormalities: a report of 5 cases with blastoid features. Mod Pathol. 2002;15:1266–1272.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Hematology, Suzuka General Hospital, 1275-53, Yasuzuka-cho, Suzuka-shi, Suzuka, Mie, Japan

    Keiki Kawakami & Shigenori Kadowaki

  2. Division of Medical Reseach, Tenri Hospital, Nara

    Setsuko Miyanishi

  3. Internal Medicine II, Kumamoto University School of Medicine, Kumamoto

    Takashi Sonoki

  4. Department of Pathology and Clinical Laboratories, Aichi Cancer Center Hospital, Nagoya

    Shigeo Nakamura

  5. Molecular Hematology and Oncology, Graduate School of Medicine, Kyoto Prefectural University of Medicine, Kyoto

    Kenichi Nomura

  6. Clinical Molecular Genetics and Laboratory Medicine, Graduate School of Medicine, Kyoto Prefectural University of Medicine, Kyoto

    Masafumi Taniwaki

  7. Divison of Pathology and Clinical Laboratories, Suzuka General Hospital, Suzuka

    Tetsuya Murata

  8. Department of Hematology and Oncology Graduate School of Medicine, Kyoto University, Kyoto

    Norimitsu Kadowaki

  9. Third Department of Internal Medicine, Akita University School of Medicine, Akita, Japan

    Ikuo Miura

Authors
  1. Keiki Kawakami
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Setsuko Miyanishi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Takashi Sonoki
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Shigeo Nakamura
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Kenichi Nomura
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Masafumi Taniwaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Tetsuya Murata
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Shigenori Kadowaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Norimitsu Kadowaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Ikuo Miura
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Keiki Kawakami.

About this article

Cite this article

Kawakami, K., Miyanishi, S., Sonoki, T. et al. Case of B-Cell Lymphoma with Rearrangement of the BCL1, BCL2, BCL6, and c-MYC Genes. Int J Hematol 79, 474–479 (2004). https://doi.org/10.1532/IJH97.03105

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1532/IJH97.03105

Key words

Search

Navigation