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Reactivation of Latent Epstein Barr Virus Infection Induces Remission of Splenic Lymphoma with Villous Lymphocytes

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Abstract

Splenic lymphoma with villous lymphocytes (SLVL) is a rare, slowly progressing, lymphoproliferative disease of B-cell origin. Treatment aimed at cure or remission is limited, and spontaneous remission has not been described. We report on a patient who after 4 years with untreated SLVL developed symptoms of mononucleosis and was found to have reactivation of latent Epstein-Barr virus (EBV) infection. During recovery from the EBV infection, complete remission from SLVL developed and lasted for 3 years, suggesting that the EBV infection induced an immune response that caused the SLVL remission.

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Authors and Affiliations

  1. Department of Hematology, Lund University Hospital, 221 84, Lund, SE, Sweden

    Markus Hansson & Inge Olsson

  2. Swedish Institute for Infectious Disease Control, Stockholm, Sweden

    Annika Linde

Authors
  1. Markus Hansson
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  2. Annika Linde
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  3. Inge Olsson
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Correspondence to Markus Hansson.

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Hansson, M., Linde, A. & Olsson, I. Reactivation of Latent Epstein Barr Virus Infection Induces Remission of Splenic Lymphoma with Villous Lymphocytes. Int J Hematol 81, 413–416 (2005). https://doi.org/10.1532/IJH97.E0434

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  • DOI: https://doi.org/10.1532/IJH97.E0434

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