ECE2024 Eposter Presentations Calcium and Bone (102 abstracts)
Influence of muscle function on bone status in patients with hypophosphatasia
Victoria Contreras Bolivar 1,2,3 , María Del Carmen Andreo-Lopez 1 , Enrique Moratalla-Aranda 2,4 , Trinidad González-Cejudo 2,5 , Luis Martínez-Heredia 2 , Francisco Andújar-Vera 2,3,6 , Cristina García-Fontana 1,2,3 , Beatriz García-Fontana 1,2,3 & Manuel Muñoz-Torres 1,2,3,7
1Endocrinology and Nutrition Unit, Hospital Universitario Clínico San Cecilio, Granada, Spain; 2Institute of Biosanitary Research of Granada (ibs.GRANADA); 3CIBER on Frailty and Healthy Ageing (CIBERFES), Instituto de Salud Carlos III, Granada, Spain; 4Nuclear Medicine Unit, Hospital Universitario Clínico San Cecilio, Granada; 5Clinical Analysis Unit, Hospital Universitario Clínico San Cecilio, Granada, Spain; 6Andalusian Institute for Research in Data Science and Computational Intelligence, Granada, Granada, Spain; 7Department of Medicine, University of Granada, Granada, Spain
Introduction: Hypophosphatasia (HPP) is characterised by a deficiency of non-tissue-specific alkaline phosphatase. This results in abnormal mineralisation of bone tissue which predisposes to fragility fractures. Moreover, an affected muscle compartment could favour the risk of fracture. The aim was to evaluate the relationship between the bone and muscle compartment.
Material and Methods: Cross-sectional study in adults with PPH. Demographic (age, sex), analytical (alkaline phosphatase-FA-) and clinical variables were collected (fractures, muscle strength measured with Jamar dynamometer in kilograms (kg) -cut-off point: <p10 of Spanish population-, muscle mass of the rectus femoris of the quadriceps with ultrasound -Sonosite S-Nerve®- and bone mineral density with dual energy X-ray absorptiometry expressed according to T and Z-score. Statistical analysis was performed with IBM SPSS v.25.
Results: Thirty-three subjects were studied, 55% women, mean age: 49±18 years and mean AF: 29±11. Fifty-one per cent had affected family members. 52% had at least one bone fracture and 67% had dental pathology. Low muscle strength was detected in 24%. The mean rectus femoris quadriceps muscle thickness was 1.4±0.7 and its mean area, 4.4±2. 22.2% (4) of the women suffered from osteopenia and 27.8% (5) from osteoporosis (OP). Of the males, 26.7% (4) had osteopenia and none had OP. Muscle strength was positively correlated with Y-axis or thickness (r=0.42, P=0.02), with muscle area (r=0.4, P=0.02), with T-score in femoral neck (r=0.48, P=0.01) and in lumbar spine (r=0.66, P=0.00). A positive correlation was even found with FA values (r=0.48, P=0.008).
Conclusions: Hand dynamometry is associated with body composition and bone parameters, and is a useful parameter for assessing muscle status in PPH patients. Therefore, given the high prevalence of fractures in PPH patients, it could be useful to enhance the muscle compartment.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more