Skip to main content

The clot thickens: an incompletely ligated left atrial appendage

Summary

Our patient presented with known mechanical mitral valve endocarditis documented by 2D transesophageal echocardiogram (TOE) from a recent hospitalization at an outside facility. On admission to our center, there was no prior knowledge of an incompletely ligated left atrial appendage (LAA) according to patient- or family-reported history, review of outside records or the outside facility’s 2D TOE report. A 3D TOE performed at our center to assess her pathology, since a month had passed from her prior hospitalization, revealed a LAA ligation with evidence of communication to the left atrium and with clot present in the appendage. This case report highlights the common finding of incomplete closure of the LAA following surgical ligation, thus making it inadequate for stroke prevention in patients with atrial fibrillation, and that 3D TOE plays a valuable role in assessing the durability of LAA ligation.

References

  1. Katz ES, Tsiamtsiouris T, Applebaum RM, Schwartzbard A, Tunick PA, Kronzon I. Surgical left atrial appendage ligation is frequently incomplete: a transesophageal echocardiographic study. Journal of the American College of Cardiology 2000 36 468–471. (https://doi.org/10.1016/S0735-1097(00)00765-8)

    Article  CAS  Google Scholar 

  2. Kanderian A, Gillinov M, Pettersson G, Blackstone E, Klein A & FACC. Success of surgical left atrial appendage closure: assessment by transesophageal echocardiography. Journal of the American College of Cardiology 2008 52 930–931. (https://doi.org/10.1016/j.jacc.2008.03.067)

    Article  Google Scholar 

  3. Aryana A, Bhaskar R. Incomplete surgical ligation of the LAA–time for a new look at an old problem. Annals of Translational Medicine 2017 5 141. (https://doi.org/10.21037/atm.2017.02.17)

    Article  Google Scholar 

  4. Aryana A, Singh SK, O’Neill PG, Bowers MR, Allen SL, owski SL, Vierra EC, d’Avila A. Association between incomplete surgical ligation of the left atrial appendage and stroke and systemic embolization. Heart Rhythm 2015 12 1431–1437. (https://doi.org/10.1016/j.hrthm.2015.03.028)

    Article  Google Scholar 

  5. Arash A, Cavaco D, O’Neill PG, Adragao P, d’Avila A. Percutaneous endocardial occlusion of incompletely surgically ligated left atrial appendage. Journal of Cardiovascular Electrophysiology 2013 24 968–974. (https://doi.org/10.1111/jce.12183)

    Article  Google Scholar 

  6. Holmes D Jr, Kar S, Price M, Whisenant B, Sievert H, Doshi S, Huber K, Reddy V. Prospective randomized evaluation of the watchman left atrial appendage closure device in patients with atrial fibrillation versus long-term warfarin therapy: the PREVAIL Trial. Journal of the American College of Cardiology 2014 64 1–12. (https://doi.org/10.1016/j.jacc.2014.04.029)

    Article  Google Scholar 

  7. Reddy VY, Doshi SK, Sievert H, Buchbinder M, Neuzil P, Huber K, Halperin JL, Holmes D & PROTECT AF Investigators. Percutaneous left atrial appendage closure for stroke prophylaxis in patients with atrial fibrillation 2.3-year follow-up of the PROTECT AF (watchman left atrial appendage system for embolic protection in patients with atrial fibrillation) Trial. Circulation 2013 127 720–729. (https://doi.org/10.1161/CIRCULATIONAHA.112.114389)

    Article  Google Scholar 

  8. Viles-Gonzalez JF, Kar S, Douglas P, Dukkipati S, Feldman T, Horton R, Holmes D, Reddy VY. The clinical impact of incomplete left atrial appendage closure with the watchman device in patients with atrial fibrillation: a PROTECT AF (percutaneous closure of the left atrial appendage versus warfarin therapy for prevention of stroke in patients with atrial fibrillation) substudy. Journal of the American College of Cardiology 2012 59 923–929. (https://doi.org/10.1016/j.jacc.2011.11.028)

    Article  Google Scholar 

  9. Shah SJ, Bardo DM, Sugeng L, Weinert L, Lodato JA, Knight BP, Lopez JJ, Lang RM. Real-time three-dimensional transesophageal echocardiography of the left atrial appendage: initial experience in the clinical setting. Journal of the American Society of Echocardiography 2008 21 1362–1368. (https://doi.org/10.1016/j.echo.2008.09.024)

    Article  Google Scholar 

  10. Nucifora G, Faletra FF, Regoli F, Pasotti E, Pedrazzini G, Moccetti T, Auricchio A. Evaluation of the left atrial appendage with real-time 3-dimensional transesophageal echocardiography: implications for catheter-based left atrial appendage closure. Circulation: Cardiovascular Imaging 2011 4 514–523. (https://doi.org/10.1161/CIRCIMAGING.111.963892)

    Google Scholar 

  11. Nakajima H, Seo Y, Ishizu T, Yamamoto M, Machino T, Harimura Y, Kawamura R, Sekiguchi Y, Tada H, Aonuma K. Analysis of the left atrial appendage by three-dimensional transesophageal echocardiography. American Journal of Cardiology 2010 106 885–892. (https://doi.org/10.1016/j.amjcard.2010.05.014)

    Article  Google Scholar 

  12. Wunderlich NC, Beigel R, Swaans MJ, Ho SY, Siegel RJ. Percutaneous interventions for left atrial appendage exclusion: options, assessment, and imaging using 2D and 3D echocardiography. Journal of the American College of Cardiology: Cardiovascular Imaging 2015 8 472–488. (https://doi.org/10.1016/j.jcmg.2015.02.002)

    Article  Google Scholar 

  13. Turton EW, Ender J. 3D role of echocardiography in cardiac surgery: strengths and limitations. Current Anesthesiology Reports 2017 7 291–298. (https://doi.org/10.1007/s40140-017-0226-5)

    Article  Google Scholar 

  14. Silvestry FE, Cohen MS, Armsby LB, Burkule NJ, Fleishman CE, Hijazi ZM, Lang RM, Rome JJ, Wang Y, American Society of Echocardiography, et al. Guidelines for the echocardiographic assessment of atrial septal defect and patent foramen ovale: from the American Society of Echocardiography and Society for Cardiac Angiography and Interventions. Journal of the American Society of Echocardiography 2015 28 910–958. (https://doi.org/10.1016/j.echo.2015.05.015)

    Article  Google Scholar 

  15. Yosefy C, Laish-Farkash A, Azhibekov Y, Khalameizer V, Brodkin B, Katz A. A new method for direct three-dimensional measurement of left atrial appendage dimensions during transesophageal echocardiography. Echocardiography 2015 33 69–76. (https://doi.org/10.1111/echo.12983)

    Article  Google Scholar 

Download references

Funding

This work did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Merrill Thomas MD.

Rights and permissions

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits use, duplication, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Thomas, M., Grodzinsky, A. & Zink, M. The clot thickens: an incompletely ligated left atrial appendage. Echo Res Pract 5, K41–K45 (2018). https://doi.org/10.1530/ERP-17-0076

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1530/ERP-17-0076

Key Words