DISCOVERIES (ISSN 2359-7232), 2016, January-March issue

CITATION: 

Submitted: March 25h, 2016; Revised: March 31st, 2016; Accepted: March 31th, 2016; Published: April 1st, 2016;

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microRNA regulators of apoptosis in cancer

Octavian Bucur*

Department of Pathology, Harvard Medical School and Beth Israel Deaconess Medical Center, Ludwig Cancer Center at Harvard, Boston, MA, USA

*Correspondence to: Octavian Bucur, PhD, MD, Department of Pathology, Harvard Medical School and Beth Israel Deaconess Medical Center, Ludwig Cancer Center at Harvard, Boston, MA, USA, Email: obucur@bidmc.harvard.edu

Abstract

This brief review summarizes our current knowledge on the microRNAs that regulate apoptosis machinery and are potentially involved in the dysregulation or deregulation of apoptosis, a well known hallmark of cancer. microRNAs are critical regulators of the most important cellular processes, including apoptosis. Expression of microRNAs is found to be dysregulated in many malignancies, leading to apoptosis inhibition in cancer, or resistance to current therapies. To date, there are over 80 microRNAs directly involved in apoptosis regulation or dysregulation that can impact cancer detection, initiation, progression, invasion, metastasis or resistance to anti-cancer therapy. Development of microRNA-based therapeutic strategies is now taking shape in the clinic. Thus, these microRNAs represent potential targets or tools for cancer therapy in the future. 

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