면역억제능을 보유한 地楡의 인슐린 분비능 연구

황석연; 김명현; 강정수; 김병수

doi:10.15188/kjopp.2014.10.28.5.499

주제분류

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저널정보

한의병리학회
동의생리병리학회지 학술저널
동의생리병리학회지 제28권 제5호
2014.10 499 - 505 (7page)
DOI : 10.15188/kjopp.2014.10.28.5.499

저자정보

황석연 (대전대학교)
김명현 (대전대학교)
강정수 (대전대학교)
김병수 (대전대학교)

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초록·키워드

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Immunosuppressors cyclosporine A(CsA) and tacrolimus(FK506), the primary cellular target of which is calcineurin/nuclear factor of activated T cells(NFAT) signalling pathways, decrease beta-cell insulin content and mRNA expression. The posttransplantation diabetes mellitus(PTDM) is a frequent complication in immunosuppressive therapy. The present study was to examine the effect of a crude water extracts of medicinal herbs such as Sanguisorba officinalis(SOE) on the immunosuppressive activity with lymphocyte and insulin secretion in insulinoma cell lines with RIN-5mF. It was found that SOE treatment had effect of immunosuppressor on lymphocytes and also significantly increased insulin secretion in RIN-5mF compared to other agents. we might suggest a mechanism on insulin secretion by HNF4a. Taken together, the present study suggested that SOE might serve as immunosuppressive drug in PTDM.

#Sanguisorba officinalis #immunosuppressor #insulin secretion #HNF-4α