Abstract
Both phenylbutazon and mofebutazon inhibit oxidative fragmentation of the methionine derivative, 2-keto-4-methylthio-butyric acid (KMB) by xanthine oxidase - or diaphorase me diated OH radical production. Differentiation of the two non-steroidal antiinflammatory drugs is possible by means of determining oxygen reduction by xanthine oxidase or diaphorase in the presence of the naphthoquinone, juglone, where only mofebutazon shows an inhibitory effect.
Keywords: Mofebutazon; Phenylbutazon; Non Steroidal Antiinflammatory Drugs (NSAIDs); Oxygen Activation
Received: 1993-5-5
Revised: 1993-6-3
Published Online: 2014-6-2
Published in Print: 1993-8-1
© 1946 – 2014: Verlag der Zeitschrift für Naturforschung
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