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Licensed Unlicensed Requires Authentication Published by De Gruyter August 10, 2018

Size-controlled atomically precise copper nanoclusters: Synthetic protocols, spectroscopic properties and applications

  • Nirmal Kumar Das

    Dr. Nirmal Kumar Das did his M. Sc. from IIT Kanpur, Kanpur in 2012. Then, he joined as a PhD scholar in IISER Bhopal under the supervision of Professor Saptarshi Mukherjee. In November 2017, he successfully defended his PhD thesis. He is currently postdoctoral fellow in the same group. His research interests include spectroscopic investigation of organized assemblies, synthesis and spectroscopic applications of luminescent metal nanoclusters.

    and Saptarshi Mukherjee

    Professor Saptarshi Mukherjee did his PhD under the supervision of Professor Kankan Bhattacharyya at IACS, Kolkata, and carried out his post-doctoral research with Professor H. Peter Lu at Bowling Green State University, Ohio, USA. He joined the Department of Chemistry, IISER Bhopal in December 2008. His research interests include luminescent metal nanoclusters, protein unfolding and refolding using ultrafast and single-molecule spectroscopy. He is presently as Professor in the Department of Chemistry, IISER Bhopal. He has received the INSA Young Scientist Medal in Chemical Sciences and is also a founding member of the Indian National Young Academy of Science.

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From the journal Physical Sciences Reviews

Abstract

Noble metal nanoclusters (NCs) are a new class of nanomaterials which are considered being a missing link between isolated metal atoms and metal nanoparticles (NPs). The sizes of the NCs are comparable to the Fermi wavelength of the conduction electrons, and this renders them to be luminescent in nature. They exhibit size-dependent fluorescence properties spanning almost the entire breath of the visible spectrum. Among all the noble metal NCs being explored, copper NCs (CuNCs) are the most rarely investigated primarily because of their propensity of getting oxidised. In this chapter, we have given a comprehensive understanding as to why these NCs are luminescent in nature. We have also given a detailed overview regarding the various templates used for the synthesis of these CuNCs along with the respective protocols being followed. The various instrumental techniques used to characterize these CuNCs are discussed which provides an in-depth understanding as to how these CuNCs can be properly examined. Finally, we have highlighted some of the most recent applications of these CuNCs which make them unique to serve as the next-generation fluorophores.

Graphical Abstract:

 The Graphical Abstract highlights some of the key spectroscopic signatures of the CuNCs and their applications.

The Graphical Abstract highlights some of the key spectroscopic signatures of the CuNCs and their applications.

About the authors

Nirmal Kumar Das

Dr. Nirmal Kumar Das did his M. Sc. from IIT Kanpur, Kanpur in 2012. Then, he joined as a PhD scholar in IISER Bhopal under the supervision of Professor Saptarshi Mukherjee. In November 2017, he successfully defended his PhD thesis. He is currently postdoctoral fellow in the same group. His research interests include spectroscopic investigation of organized assemblies, synthesis and spectroscopic applications of luminescent metal nanoclusters.

Saptarshi Mukherjee

Professor Saptarshi Mukherjee did his PhD under the supervision of Professor Kankan Bhattacharyya at IACS, Kolkata, and carried out his post-doctoral research with Professor H. Peter Lu at Bowling Green State University, Ohio, USA. He joined the Department of Chemistry, IISER Bhopal in December 2008. His research interests include luminescent metal nanoclusters, protein unfolding and refolding using ultrafast and single-molecule spectroscopy. He is presently as Professor in the Department of Chemistry, IISER Bhopal. He has received the INSA Young Scientist Medal in Chemical Sciences and is also a founding member of the Indian National Young Academy of Science.

Acknowledgements

The authors sincerely thank the research facilities of IISER Bhopal and the Central Instrumentation Facility (CIF), IISER Bhopal. NKD thanks UGC, Govt. of India for research fellowship. SM thanks Indian National Science Academy (Grant No. INSA/CHM/2015045) for providing financial support. SM also thanks the past and present members of the group with a special mention of Dr Subhadip Ghosh and Dr Uttam Anand for their valuable contributions in the works related to the NCs.

References

[1] Kreibig U, Vollmer M. Optical properties of metal clusters. Berlin, Germany: Springer, 1995.10.1007/978-3-662-09109-8Search in Google Scholar

[2] Bhattacharyya K, Mukherjee S. Fluorescent metal nano-clusters as next generation fluorescent probes for cell imaging and drug delivery. Bull Chem Soc Jpn. 2018 3 15;91:447–54. DOI: 10.1246/bcsj.20170377.Search in Google Scholar

[3] Ghosh SK, Pal T. Interparticle coupling effect on the surface plasmon resonance of gold nanoparticles: from theory to applications. Chem Rev. 2007;107:4797–862.10.1021/cr0680282Search in Google Scholar PubMed

[4] Schmid G. Clusters and colloids-From theory to applications. Weinheim, Germany: VCH, 1994.10.1002/9783527616077Search in Google Scholar

[5] Zheng J, Nicovich PR, Dickson RM. Highly fluorescent noble-metal quantum dots. Annu Rev Phys Chem. 2007;58:409–13.10.1146/annurev.physchem.58.032806.104546Search in Google Scholar PubMed PubMed Central

[6] Haberland H. Clusters of atoms and molecules. Berlin, Germany: Springer, 1994.10.1007/978-3-642-84329-7Search in Google Scholar

[7] Schaaff TG, Knight G, Shafigullin MN, Borkman RF, Whetten RL. Isolation and selected properties of a 10.4 kDa gold:glutathione cluster compound. J Phys Chem B. 1998;102:10643–6.10.1021/jp9830528Search in Google Scholar

[8] Chakraborty I, Pradeep T. Atomically precise clusters of noble metals: emerging link between atoms and nanoparticles. Chem Rev. 2017;117:8208–71.10.1021/acs.chemrev.6b00769Search in Google Scholar PubMed

[9] Wallace WT, Whetten RL. Coadsorption of CO and O2 on selected gold clusters: evidence for efficient room-temperature CO2 generation. J Am Chem Soc. 2002;124:7499–505.10.1021/ja0175439Search in Google Scholar PubMed

[10] Campbell CT, Parker SC, Starr DE. The effect of size-dependent nanoparticle energetics on catalyst sintering. Science. 2002;298:811–4.10.1126/science.1075094Search in Google Scholar PubMed

[11] Link S, Beeby A, FitzGerald S, Sayed MAE, Schaaff TG, Whetten RL. Visible to infrared luminescence from a 28-atom gold cluster. J Phys Chem B. 2002;106:3410–5.10.1021/jp014259vSearch in Google Scholar

[12] Peyser LA, Lee TH, Dickson RM. Mechanism of Agn nanocluster photoproduction from silver oxide films. J Phys Chem B. 2002;106:7725–8.10.1021/jp026111xSearch in Google Scholar

[13] Félix C, Sieber C, Harbich W, Buttet J, Rabin I, Schulze W, et al. Ag8 fluorescence in argon. Phys Rev Lett. 2001;86:2992.10.1103/PhysRevLett.86.2992Search in Google Scholar PubMed

[14] Fedrigo S, Harbich W, Buttet J. Optical response of Ag2, Ag3, Au2, and Au3 in argon matrices. J Chem Phys. 1993;99:5712–7.10.1063/1.465920Search in Google Scholar

[15] Ishida Y, Corpuz RD, Yonezawa T. Matrix sputtering method: A novel physical approach for photoluminescent noble metal nanocluster. Acc Chem Res. 2017;50:2986–95.10.1021/acs.accounts.7b00470Search in Google Scholar PubMed

[16] Zheng J, Chen Z, Yu M, Liu J. Different sized luminescent gold nanoparticles. Nanoscale. 2012;4:4073–83.10.1039/c2nr31192eSearch in Google Scholar PubMed PubMed Central

[17] Johnson PB, Christy RW. Optical constants of the noble metals. Phys Rev. 1972;B6:4370–9.10.1103/PhysRevB.6.4370Search in Google Scholar

[18] March A. Electron theory of metals. Ann Phys. 1916;354:710–24.10.1002/andp.19163540607Search in Google Scholar

[19] Khandelwal P, Poddar P. Fluorescent metal quantum clusters: an updated overview of the synthesis, properties, and biological applications. J Mater Chem B. 2017;5:9055–84.10.1039/C7TB02320KSearch in Google Scholar

[20] Zheng J, Zhang CW, Dickson RM. Highly fluorescent, water-soluble, size tunable gold quantum dots. Phys Review Lett. 2004;93:077402.10.1103/PhysRevLett.93.077402Search in Google Scholar PubMed

[21] Johnston RL. Atomic and molecular clusters. London: Taylor & Francis, 2002.10.1201/9780367805814Search in Google Scholar

[22] Knight WD, Clemenger K, De Heer WA, Saunders WA, Chou MY, Cohen ML. Electronic shell structure and abundances of sodium clusters. Phys Review Lett. 1984;52:2141.10.1103/PhysRevLett.52.2141Search in Google Scholar

[23] De Heer WA, Selby K, Kresin V, Masui J, Vollmer M, Chatelain A, et al. Collective dipole oscillations in small sodium clusters. Phys Review Lett. 1987;59:1805.10.1103/PhysRevLett.59.1805Search in Google Scholar PubMed

[24] De Heer WA. The physics of simple metal clusters: experimental aspects and simple models. Rev Mod Phys. 1993;65:611–76.10.1103/RevModPhys.65.611Search in Google Scholar

[25] Kiejna A, Wojciechowski KF. Metal surface electron physics. Pergamon, United Kingdom 1996.10.1016/B978-008042675-4/50000-1Search in Google Scholar

[26] Lang N, Kohn W. Theory of metal surfaces: charge density and surface energy. Phys Rev B. 1970;1:4555–68.10.1103/PhysRevB.1.4555Search in Google Scholar

[27] Ashcroft NW, Wood DM. Quantum size effects in the optical properties of small metallic particles. Phys Rev B. 1982;25:6255–74.10.1103/PhysRevB.25.6255Search in Google Scholar

[28] Chattoraj S, Bhattacharyya K. Fluorescent gold nanocluster inside a live breast cell: etching and higher uptake in cancer cell. J Phys Chem C. 2014;118:22339–46.10.1021/jp506745pSearch in Google Scholar

[29] Chattoraj S, Amin MA, Bhattacharyya K. Cytochrome C-capped fluorescent gold nanoclusters: imaging of live cells and delivery of cytochrome C. ChemPhysChem. 2016;17:2088–95.10.1002/cphc.201501163Search in Google Scholar PubMed

[30] Chattoraj S, Amin MA, Jana B, Mohapatra S, Ghosh S, Bhattacharyya K. Selective killing of breast cancer cells by Doxorubicin-loaded fluorescent gold nanoclusters: confocal microscopy and FRET. ChemPhysChem. 2016;17:253–9.10.1002/cphc.201500982Search in Google Scholar PubMed

[31] Fedrigo S, Harbich W, Buttet J. Recent development in deciphering the structure of luminescent silver nanodots. J Chem Phys. 1993;99:5712–17.10.1063/1.465920Search in Google Scholar

[32] Lin C-AJ, Lee C-H, Hsieh J-T, Wang -H-H, Li JK, Shen J-L, et al. Synthesis of fluorescent metallic nanoclusters toward biomedical application: recent progress and present challenges. J Med Biol Eng. 2009;29:276–83.Search in Google Scholar

[33] Anand U, Ghosh S, Mukherjee S. Toggling between blue- and red-emitting fluorescent silver nanoclusters. J Phys Chem Lett. 2012;3:3605–9.10.1021/jz301733ySearch in Google Scholar PubMed

[34] Ghosh S, Das NK, Anand U, Mukherjee S. Photostable copper nanoclusters: compatible Förster resonance energy-transfer assays and a nanothermometer. J Phys Chem Lett. 2015;6:1293–8.10.1021/acs.jpclett.5b00378Search in Google Scholar PubMed

[35] Das NK, Ghosh S, Priya A, Datta S, Mukherjee S. Luminescent copper nanoclusters as a specific cell-imaging probe and a selective metal ion sensor. J Phys Chem C. 2015;119:24657–64.10.1021/acs.jpcc.5b08123Search in Google Scholar

[36] Ghosh S, Anand U, Mukherjee S. Luminescent silver nanoclusters acting as a label-free photoswitch in metal ion sensing. Anal Chem. 2014;86:3188–94.10.1021/ac500122vSearch in Google Scholar PubMed

[37] Ghoshal A, Goswami U, Sahoo AK, Chattopadhyay A, Ghosh SS. Targeting Wnt canonical signaling by recombinant sFRP1 bound luminescent Au-Nanocluster embedded nanoparticles in cancer theranostics. ACS Biomater Sci Eng. 2015;1:1256–66.10.1021/acsbiomaterials.5b00305Search in Google Scholar PubMed

[38] Leung FC-M, Tam A-Y-Y, Au VK-M, Li M-J, Yam V-W-W. Förster resonance energy transfer studies of luminescent gold nanoparticles functionalized with ruthenium(II) and rhenium(I) complexes: modulation via esterase hydrolysis. ACS Appl Mater Interfaces. 2014;6:6644–53.10.1021/am500350cSearch in Google Scholar PubMed

[39] Su Y, Qi L, Mubc X, Wang M. A fluorescent probe for sensing ferric ions in bean sprouts based on L-histidine-stabilized gold nanoclusters. Anal Methods. 2015;7:684–9.10.1039/C4AY02186JSearch in Google Scholar

[40] Yao Q, Yuan X, Fung V, Yu Y, Leong DT, Jiang D, et al. Understanding seed-mediated growth of gold nanoclusters at molecular level. Nat Commun. 2017;8:927.10.1038/s41467-017-00970-1Search in Google Scholar PubMed PubMed Central

[41] Fabris L, Antonello S, Armelao L, Donkers RL, Polo F, Toniolo C, et al. Gold nanoclusters protected by conformationally constrained peptides. J Am Chem Soc. 2005, 2006;128:326–36.10.1021/ja0560581Search in Google Scholar PubMed

[42] Kundu S, Maheshwari V, Saraf RF. Photolytic metallization of Au nanoclusters and electrically conducting micrometer long nanostructures on a DNA scaffold. Langmuir. 2008;24:551–5.10.1021/la702416zSearch in Google Scholar PubMed

[43] Lin C-AJ, Yang T-Y, Lee C-H, Sherry HH, Sperling RA, Zanella M, et al. Synthesis, characterization, and bioconjugation of fluorescent gold nanoclusters toward biological labeling applications. ACS Nano. 2009;3:395–401.10.1021/nn800632jSearch in Google Scholar PubMed

[44] Shang L, Brandholt S, Stockmar F, Trouillet V, Bruns M, Nienhaus GU. Effect of protein adsorption on the fluorescence of ultrasmall gold nanoclusters. Small. 2012;8:661–5.10.1002/smll.201101353Search in Google Scholar PubMed

[45] Liu Y-Q, Zhang M, Yin B-C, Ye B-C. Attomolar ultrasensitive microRNA detection by DNA-scaffolded silver-nanocluster probe based on isothermal amplification. Anal Chem. 2012;84:5165–9.10.1021/ac300483fSearch in Google Scholar PubMed

[46] Liu G, Feng D-Q, Chen T, Li D, Zheng W. DNA-templated formation of silver nanoclusters as a novel light-scattering sensor for label-free copper ions detection. J Material Chem. 2012;22:20885–8.10.1039/c2jm35236bSearch in Google Scholar

[47] Ghoshal A, Goswami U, Raza A, Chattopadhyay A, Ghosh SS. Recombinant sFRP4 bound chitosan-alginate composite nanoparticles embedded with silver nanoclusters for Wnt/b-catenin targeting in cancer theranostics. RSC Adv. 2016;6:85763–72.10.1039/C6RA16066BSearch in Google Scholar

[48] Sarkar S, Chakraborty I, Panwar MK, Pradeep T. Isolation and tandem mass spectrometric identification of a stable monolayer protected silver-palladium alloy cluster. J Phys Chem Lett. 2014;5:3757–62.10.1021/jz5019509Search in Google Scholar PubMed

[49] Shang L, Dörlich RM, Trouillet V, Bruns M, Nienhaus GU. Ultrasmall fluorescent silver nanoclusters: protein adsorption and its effects on cellular responses. Nano Res. 2012;5:531–42.10.1007/s12274-012-0238-xSearch in Google Scholar

[50] Zheng K, Setyawati M, Lim T-P, Leong DT, Xie J. Antimicrobial cluster bombs: silver nanoclusters packed with daptomycin. ACS Nano. 2016;10:7934–42.10.1021/acsnano.6b03862Search in Google Scholar PubMed

[51] Kawasaki H, Kosaka Y, Myoujin Y, Narushima T, Yonezawa T, Arakawa R. Microwave-assisted polyol synthesis of copper nanocrystals without using additional protective agents. Chem Commun. 2011;47:7740–2.10.1039/c1cc12346gSearch in Google Scholar PubMed

[52] Das NK, Chakraborty S, Mukherjee M, Mukherjee S. Enhanced luminescent properties of photo-stable copper nanoclusters through formation of “Protein-Corona”-like assemblies. 2018: DOI: 10.1002/cphc.201800332.10.1002/cphc.201800332Search in Google Scholar PubMed

[53] Guo Y, Cao F, Lei X, Mang L, Cheng S, Song J. Fluorescent copper nanoparticles: recent advances in synthesis and applications for sensing metal ions. Nanoscale. 2016;8:4852–63.10.1039/C6NR00145ASearch in Google Scholar PubMed

[54] Salzemann C, Lisiecki I, Brioude A, Urban J, Pileni M-P. Collections of copper nanocrystals characterized by different sizes and shapes: optical response of these nanoobjects. J Phys Chem B. 2004;108:13242–8.10.1021/jp048491nSearch in Google Scholar

[55] Salzemann C, Brioude A, Pileni M-P. Tuning of copper nanocrystals optical properties with their shapes. J Phys Chem B. 2006;110:7208–12.10.1021/jp0601567Search in Google Scholar PubMed

[56] Salzemann C, Lisiecki I, Urban J, Pileni M-P. Anisotropic copper nanocrystals synthesized in a supersaturated medium: nanocrystal growth. Langmuir. 2004;20:11772–7.10.1021/la0492862Search in Google Scholar PubMed

[57] Liu X, Astruc D. Atomically precise copper nanoclusters and their applications. Co-Ordination Chem Rev. 2018;359:112–26.10.1016/j.ccr.2018.01.001Search in Google Scholar

[58] Wang Z, Chen B, Rogach AL. Synthesis, optical properties and applications of light-emitting copper nanoclusters. Nanoscale Horizons. 2017;2:135–46.10.1039/C7NH00013HSearch in Google Scholar PubMed

[59] Hu X, Liu T, Zhuang Y, Wang W, Li Y, Fan W, et al. Recent advances in the analytical applications of copper nanoclusters. Trends Anal Chem. 2016;77:66–75.10.1016/j.trac.2015.12.013Search in Google Scholar

[60] Qu X, Li Y, Li L, Wang Y, Liang J, Liang J. Fluorescent gold nanoclusters: synthesis and recent biological application. J Nanomater. 2015;2015:784097.10.1155/2015/784097Search in Google Scholar

[61] Schaaff TG, Whetten RL. Controlled etching of Au: sRcluster compounds. J Phys Chem B. 1999;103:9394–6.10.1021/jp993229dSearch in Google Scholar

[62] Luo Z, Yuan X, Yu Y, Zhang Q, Leong DT, Lee JY, et al. From aggregation-induced emission of Au(I)-thiolate complexes to ultrabright Au(0)@Au(I)-thiolate core-shell nanoclusters. J Am Chem Soc. 2012;134:16662–70.10.1021/ja306199pSearch in Google Scholar PubMed

[63] Rao TUB, Pradeep T. Luminescent Ag7 and Ag8 clusters by interfacial synthesis. Angewantde Chemie Int Edition. 2010;49:3925–9.10.1002/anie.200907120Search in Google Scholar PubMed

[64] Jupally VR, Dass A. Synthesis of Au130(SR)50 and Au130-xAgx(SR)50 nanomolecules through core size conversion of larger metal clusters. Phys Chem Chem Phys. 2014;16:10473–9.10.1039/C3CP54343ASearch in Google Scholar PubMed

[65] Wang B, Gui R, Jin H, He W, Wang Z. Red-emitting BSA-stabilized copper nanoclusters acted as a sensitive probe for fluorescence sensing and visual imaging detection of rutin. Talanta. 2018;178:1006–10.10.1016/j.talanta.2017.08.102Search in Google Scholar PubMed

[66] Wang C, Wang C, Xu L, Cheng H, Lin Q, Zhang C. Protein-directed synthesis of pH-responsive red fluorescent copper nanoclusters and their applications in cellular imaging and catalysis. Nanoscale. 2014;6:1775–81.10.1039/C3NR04835GSearch in Google Scholar PubMed

[67] Goswami N, Giri A, Bootharaju MS, Xavier PL, Pradeep T, Pal SK. Copper quantum clusters in protein matrix: potential sensor of Pb2+ ion. Anal Chem. 2011;83:9676–80.10.1021/ac202610eSearch in Google Scholar PubMed

[68] Gao Z, Su R, Qi W, Wang L, He Z. Copper nanocluster-based fluorescent sensors for sensitive and selective detection of kojic acid in food stuff. Sensors Actuators B. 2014;195:359–64.10.1016/j.snb.2014.01.051Search in Google Scholar

[69] Mu˜noz-Bustos C, Tirado-Guízar A, Paraguay-Delgado F, Pina-Luis G. Copper nanoclusters-coated BSA as a novel fluorescence sensor for sensitive and selective detection of mangiferin. Sensors Actuators B. 2017;244:922–7.10.1016/j.snb.2017.01.071Search in Google Scholar

[70] Zhao M, Chen A-Y, Huang D, Zhuo Y, Chai Y-Q, Yuan R. Cu nanoclusters: novel electrochemiluminescence emitters for bioanalysis. Anal Chem. 2016;88:11527–32.10.1021/acs.analchem.6b02770Search in Google Scholar PubMed

[71] Xiaoqing L, Ruiyi L, Zaijun L, Xiulan S, Zhouping W, Junkangc L. Fast synthesis of copper nanoclusters through the use of hydrogen peroxide additive and their application for the fluorescence detection of Hg2+ in water samples. New J Chem. 2015;39:5240–8.10.1039/C5NJ00831JSearch in Google Scholar

[72] Ruiyi L, Huiying W, Xiaoyan Z, Xiaoqing L, Xiulanb S, Zaijun L. D-Penicillamine and bovine serum albumin co-stabilized copper nanoclusters with remarkably enhanced fluorescence intensity and photostability for ultrasensitive detection of Ag+. New J Chem. 2016;40:732–9.10.1039/C5NJ02615FSearch in Google Scholar

[73] Gao F, Cai P, Yang W, Xue J, Gao L, Liu R, et al. Ultrasmall [64Cu]Cu nanoclusters for targeting orthotopic lung tumors using accurate positron emission tomography imaging. ACS Nano. 2015;9:4976–86.10.1021/nn507130kSearch in Google Scholar PubMed

[74] Ghosh R, Sahoo AK, Ghosh SS, Paul A, Chattopadhyay A. Blue-emitting copper nanoclusters synthesized in the presence of lysozyme as candidates for cell labelling. ACS Appl Mater Interfaces. 2014;6:3822–8.10.1021/am500040tSearch in Google Scholar PubMed

[75] Wang C, Shu S, Yao Y, Song Q. A fluorescent biosensor of lysozyme-stabilized copper nanoclusters for the selective detection of glucose. RSC Adv. 2015;5:101599–606.10.1039/C5RA19421KSearch in Google Scholar

[76] Miao H, Zhong D, Zhoub Z, Yang X. Papain-templated Cu nanoclusters: assaying and exhibiting dramatic antibacterial activity cooperating with H2O2. Nanoscale. 2015;7:19066–72.10.1039/C5NR05362ESearch in Google Scholar PubMed

[77] Zhao T, He X-Y, Li W-Y, Zhangab Y-K. Transferrin-directed preparation of red-emitting copper nanoclusters for targeted imaging of transferrin receptor over-expressed cancer cells. J Mater Chem B. 2015;3:2388–94.10.1039/C4TB02130DSearch in Google Scholar PubMed

[78] Wang W, Leng F, Zhan L, Chang Y, Yang XX, Lana J, et al. One-step prepared fluorescent copper nanoclusters for reversible pH-sensing. Analyst. 2014;139:2990–3.10.1039/C4AN00113CSearch in Google Scholar PubMed

[79] Huang H, Li H, Wang A-J, Zhong S-X, Fang K-M, Feng JJ. Green synthesis of peptide-templated fluorescent copper nanoclusters for temperature sensing and cellular imaging. Analyst. 2014;139:6536–41.10.1039/C4AN01757ASearch in Google Scholar PubMed

[80] Petty JT, Zheng J, Hud NV, Dickson RM. DNA-templated Ag nanocluster formation. J Am Chem Soc. 2004;126:5207–12.10.1021/ja031931oSearch in Google Scholar PubMed

[81] Jia X, Li J, Han L, Ren J, Yang X, Wang E. DNA-hosted copper nanoclusters for fluorescent identification of single nucleotide polymorphisms. ACS Nano. 2012;6:3311–7.10.1021/nn3002455Search in Google Scholar PubMed

[82] Lan G-Y, Chen W-Y, Chang H-T. Characterization and application to the detection of single-stranded DNA binding protein of fluorescent DNA-templated copper/silver nanoclusters. Analyst. 2011;136:3623–8.10.1039/c1an15258kSearch in Google Scholar PubMed

[83] Chen J, Liu J, Fang Z, Zeng L. Random dsDNA-templated formation of copper nanoparticles as novel fluorescence probes for label-free lead ions detection. Chem Commun. 2012;48:1057–9.10.1039/C2CC16668BSearch in Google Scholar PubMed

[84] Jia X, Yang X, Li J, Li D, Wang D. Stable Cu nanoclusters: from an aggregation induced emission mechanism to biosensing and catalytic applications. Chem Commun. 2014;50:237–9.10.1039/C3CC47771ASearch in Google Scholar PubMed

[85] Wei W, Lu Y, Chen W, Chen S. One-pot synthesis, photoluminescence, and electrocatalytic properties of subnanometer-sized copper clusters. J Am Chem Soc. 2011;133:2060–3.10.1021/ja109303zSearch in Google Scholar PubMed

[86] Lin Y-J, Chen P-C, Yuan Z, Ma JY, Chang H-T. The isomeric effect of mercaptobenzoic acids on the preparation and fluorescence properties of copper nanoclusters. Chem Commun. 2015;51:11983–6.10.1039/C5CC02342DSearch in Google Scholar PubMed

[87] Hu X, Mao X, Zhang X, Huang Y. One-step synthesis of orange fluorescent copper nanoclusters for sensitive and selective sensing of Al3+ ions in food samples. Sensors Actuators B. 2017;247:312–8.10.1016/j.snb.2017.03.050Search in Google Scholar

[88] Huang Y, Liu W, Feng H, Ye Y, Tang C, Ao H, et al. Luminescent nanoswitch based on organic-phase copper nanoclusters for sensitive detection of trace amount of water in organic solvents. Anal Chem. 2016;88:7429–34.10.1021/acs.analchem.6b02149Search in Google Scholar PubMed

[89] Jia X, Li Z, Wang E. Cu Nanoclusters with aggregation induced emission enhancement. Small. 2013;9:3873–9.10.1002/smll.201300896Search in Google Scholar PubMed

[90] Huang H, Li H, Feng -J-J, Feng H, Wang A-J, Qian Z. One-pot green synthesis of highly fluorescent glutathione-stabilized copper nanoclusters for Fe3+ sensing. Sensors Actuators B. 2016;241:292–7.10.1016/j.snb.2016.10.086Search in Google Scholar

[91] Ye Y, Dong X, Jiang H, Wang X. An intracellular temperature nano probe based on biosynthesized fluorescent copper nanoclusters. J Mater Chem B. 2017;5:691–6.10.1039/C6TB02751BSearch in Google Scholar PubMed

[92] Zhou T, Yao Q, Zhao T, Chen X. One-pot synthesis of fluorescent DHLA-stabilized Cu nanoclusters for the determination of H2O2. Talanta. 2015;141:80–5.10.1016/j.talanta.2015.03.056Search in Google Scholar PubMed

[93] Guan W, Zhou W, Lu J, Lu C. Luminescent films for chemo and biosensing. Chem Soc Rev. 2015;44:6981–7009.10.1039/C5CS00246JSearch in Google Scholar PubMed

[94] Cao DH, Stoumpos CC, Farha OK, Hupp JT, Kanatzidis MG. 2D homologous perovskites as light-absorbing materials for solar cell applications. J Am Chem Soc. 2015;137:7843–50.10.1021/jacs.5b03796Search in Google Scholar PubMed

[95] Hedley GJ, Ruseckas A, Samuel IDW. Light harvesting for organic photovoltaics. Chem Rev. 2017;117:796–837.10.1021/acs.chemrev.6b00215Search in Google Scholar PubMed PubMed Central

[96] Xiao Z, Kerner RA, Zhao L, Tran NL, Lee KM, Koh T-W, et al. Efficient perovskite light-emitting diodes featuring nanometre-sized crystallites. Nat Photonics. 2017;11:108–15.10.1038/nphoton.2016.269Search in Google Scholar

[97] Zhao L, Yeh Y-W, Tran NL, Wu F, Xiao Z, Kerner RA, et al. In situ preparation of metal halide perovskite nanocrystal thin films for improved light-emitting devices. ACS Nano. 2017;11:3957–64.10.1021/acsnano.7b00404Search in Google Scholar PubMed

[98] Wang Z, Stephen Y, Kershaw V, Chen B, Yang X, Goswami N, et al. In situ fabrication of flexible, thermally stable, large-area, strongly luminescent copper nanocluster/polymer composite films. Chem Mater. 2017;29:10206–11.10.1021/acs.chemmater.7b04239Search in Google Scholar

[99] Barthel MJ, Angeloni I, Petrelli A, Avellini T, Scarpellini A, Bertoni G, et al. Synthesis of highly fluorescent copper clusters using living polymer chains as combined reducing agents and ligands. ACS Nano. 2015;9:11886–97.10.1021/acsnano.5b04270Search in Google Scholar PubMed

[100] Ghosh R, Goswami U, Ghosh SS, Paul A, Chattopadhyay A. Synergistic anticancer activity of fluorescent copper nanoclusters and cisplatin delivered through a hydrogel nanocarrier. ACS Appl Mater Interfaces. 2015;7:209–22.10.1021/am505799qSearch in Google Scholar PubMed

[101] Ling Y, Wu JJ, Gao ZF, Li NB, Luo HQ. Enhanced emission of polyethyleneimine-coated copper nanoclusters and their solvent effect. J Phys Chem C. 2015;119:27173–7.10.1021/acs.jpcc.5b09488Search in Google Scholar

[102] Jin R. Atomically precise metal nanoclusters: stable sizes and optical properties. Nanoscale. 2015;7:1549–65.10.1039/C4NR05794ESearch in Google Scholar PubMed

[103] Chen P-C, Periasamy AP, Harroun SG, Wu W-P, Chang H-T. Photoluminescence sensing systems based on copper, gold and silver nanomaterials. Coord Chem Rev. 2016;320-321:129–38.10.1016/j.ccr.2015.12.002Search in Google Scholar

[104] Ghosh S, Anand U, Mukherjee S. Kinetic aspects of enzyme-mediated evolution of highly luminescent meta silver nanoclusters. J Phys Chem C. 2015;119:10776–84.10.1021/acs.jpcc.5b03594Search in Google Scholar

[105] O’ Connor DV, Phillips D. Time correlated single photon counting. New York: Academic Press, 1994.Search in Google Scholar

[106] Lakowicz JR. Principles of fluorescence spectroscopy. USA: Springer, 2006.10.1007/978-0-387-46312-4Search in Google Scholar

[107] Jin R, Zeng C, Zhou M, Chen Y. Atomically precise colloidal metal nanoclusters and nanoparticles: fundamentals and opportunities. Chem Rev. 2016;116:10346–413.10.1021/acs.chemrev.5b00703Search in Google Scholar PubMed

[108] Schaaff TG, Shafigullin MN, Khoury JT, Vezmar I, Whetten RL, Cullen WG, et al. Isolation of smaller nanocrystal au molecules: robust quantum effects in optical spectra. J Phys Chem B. 1997;101:7885–91.10.1021/jp971438xSearch in Google Scholar

[109] Dass A, Stevenson A, Dubay GR, Tracy JB, Murray RW. Nanoparticle MALDI-TOF mass spectrometry without fragmentation: au25(SCH2CH2Ph)18 and mixed monolayer Au25(SCH2CH2Ph)18-x(L)x. J Am Chem Soc. 2008;130:5940–6.10.1021/ja710323tSearch in Google Scholar PubMed

[110] Franz H, Michael K, Ronald CB, Brian TC. Matrix-assisted laser desorption/ionization mass spectrometry of biopolymers. Anal Chem. 1991;63:1193–203.10.1021/ac00024a716Search in Google Scholar

[111] Lu Y, Chen W. Application of mass spectrometry in the synthesis and characterization of metal nanoclusters. Anal Chem. 2015;87:10659–67.10.1021/acs.analchem.5b00848Search in Google Scholar PubMed

[112] Goswami U, Dutta A, Raza A, Kandimalla R, Kalita S, Ghosh SS, et al. Transferrin-copper nanocluster-doxorubicin nanoparticles as targeted theranostic cancer nanodrug. ACS Appl Mater Interfaces. 2018;10:3282–94.10.1021/acsami.7b15165Search in Google Scholar PubMed

[113] Kong L, Chu X, Wang C, Zhou H, Wu Y, Liu L. D-Penicillamine-coated Cu/Ag alloy nanocluster superstructures: aggregation-induced emission and tunable photoluminescence from red to orange. Nanoscale. 2018;10:1631–40.10.1039/C7NR08434JSearch in Google Scholar PubMed

[114] Cook AW, Jones ZR, Wu G, Scott SL, Hayton TW. An organometallic Cu20 nanocluster: synthesis, characterization, immobilization on silica, and “click” chemistry. J Am Chem Soc. 2018;140:394–400.10.1021/jacs.7b10960Search in Google Scholar PubMed

[115] Diamond D. Principles of chemical and biological sensors. New York, USA: John Wiley & Sons, 1998.Search in Google Scholar

[116] Sapsford KE, Bradburne C, Detehanty JB, Medintz IL. Sensors for detecting biological agent. Mater Today. 2008;11:38–49.10.1016/S1369-7021(08)70018-XSearch in Google Scholar

[117] De M, Ghosh PS, Rotello VM. Applications of nanoparticles in biology. Adv Mater. 2008;20:4225–41.10.1002/adma.200703183Search in Google Scholar

[118] Thomas SW, Joly GD, Swager TM. Chemical sensors based on amplifying fluorescent conjugated polymers. Chem Rev. 2007;107:1339–86.10.1021/cr0501339Search in Google Scholar PubMed

[119] Ghosh SK, Rahman DS, Ali AL, Kalita A. Surface plasmon tunability and emission sensitivity of ultrasmall fluorescent copper nanoclusters. Plasmonics. 2013;8:1457–68.10.1007/s11468-013-9559-1Search in Google Scholar

[120] Li D, Li B, Yang SI. A selective fluorescence turn-on sensing system for evaluation of Cu2+ polluted water based on ultra-fast formation of fluorescent copper nanoclusters. Anal Methods. 2015;7:2278–82.10.1039/C5AY00219BSearch in Google Scholar

[121] Zhong YP, Zhu JJ, Wang QP, He Y, Ge YL, Song CW. Copper nanoclusters coated with bovine serum albumin as a regenerable fluorescent probe for copper (II) ion. Microchimica Acta. 2015;182:909–15.10.1007/s00604-014-1407-2Search in Google Scholar

[122] Cao H, Chen Z, Zheng H, Huang Y. Copper nanoclusters as a highly sensitive and selective fluorescence sensor for ferric ions in serum and living cells by imaging. Biosens Bioelectron. 2014;62:189–95.10.1016/j.bios.2014.06.049Search in Google Scholar PubMed

[123] Feng J, Ju Y, Liu J, Zhang H, Chen X. Polyethyleneimine-templated copper nanoclusters via ascorbic acid reduction approach as ferric ion sensor. Anal Chim Acta. 2015;854:153–60.10.1016/j.aca.2014.11.024Search in Google Scholar PubMed

[124] Cui M, Song G, Wang C, Song Q. Synthesis of cysteine-functionalized water-soluble luminescent copper nanoclusters and their application to the determination of chromium (VI). Microchimica Acta. 2015;182:1371–7.10.1007/s00604-015-1458-zSearch in Google Scholar

[125] Zhong Y, Wang Q, He Y, Ge Y, Song G. A novel fluorescence and naked eye sensor for iodide in urine based on the iodide induced oxidative etching and aggregation of Cu nanoclusters. Sensors Actuators B. 2015;209:147–53.10.1016/j.snb.2014.11.060Search in Google Scholar

[126] Li Z, Guo S, Lu C. A highly selective fluorescent probe for sulfide ions based on aggregation of Cu nanocluster induced emission enhancement. Analyst. 2015;140:2719–25.10.1039/C5AN00017CSearch in Google Scholar PubMed

[127] Wang CX, Cheng H, Huang YJ, Xu ZZ, Lin HH, Zhang C. Facile sonochemical synthesis of pH-responsive copper nanoclusters for selective and sensitive detection of Pb2+ in living cells. Analyst. 2015;140:5634–9.10.1039/C5AN00741KSearch in Google Scholar

[128] Liao X, Rui L, Long X, Li Z. Ultrasensitive and wide-range pH sensor based on the BSA-capped Cu nanoclusters fabricated by fast synthesis through the use of hydrogen peroxide additive. RSC Adv. 2015;5:48835–41.10.1039/C5RA07966GSearch in Google Scholar

[129] Liu J. DNA-stabilized, fluorescent, metal nanoclusters for biosensor development. Trends Anal Chem. 2014;58:99–111.10.1016/j.trac.2013.12.014Search in Google Scholar

[130] Wang XP, Yin BC, Ye BC. A novel fluorescence probe of dsDNA-templated copper nanoclusters for quantitative detection of microRNAs. RSC Adv. 2013;3:8633–6.10.1039/c3ra23296dSearch in Google Scholar

[131] Zhang H, Lin Z, Su X. Label-free detection of exonuclease III by using dsDNA-templated copper nanoparticles as fluorescent probe. Talanta. 2015;131:59–63.10.1016/j.talanta.2014.07.065Search in Google Scholar PubMed

[132] Bhamore JR, Jha S, Mungara AK, Singhal RK, Sonkeshariya D, Kailasa SK. One-step green synthetic approach for the preparation of multicolor emitting copper nanoclusters and their applications in chemical species sensing and bioimaging. Biosens Bioelectron. 2016;80:243–8.10.1016/j.bios.2016.01.066Search in Google Scholar PubMed

[133] Shi Y, Luo S, Ji X, Liu F, Chen X, Huang Y, et al. Synthesis of ultra-stable copper nanoclusters and their potential application as a reversible thermometer. Dalton Trans. 2017;46:14251–5.10.1039/C7DT02193CSearch in Google Scholar PubMed

Published Online: 2018-08-10

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