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Abstract
A brief review of the molecular mechanisms of nickel carcinogenesis is presented. Molecular mechanisms of nickel carcinogenesis are considered from the pointofview of nickelinduced gene silencing by DNA hypermethylation in mammalian cells and by its ability to inhibit histone acetylation. Model systems designed to study the molecular mechanism of gene silencing are discussed.
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Published Online: 2005-06-01
Published in Print: 2002-06-26
Copyright © 2002 by Walter de Gruyter GmbH & Co. KG
