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Licensed Unlicensed Requires Authentication Published by De Gruyter July 1, 1992

Methyltransferase pharmacogenetics

  • R. Weinshilboum,
From the journal Journal of Basic and Clinical Physiology and Pharmacology
https://doi.org/10.1515/JBCPP.1992.3.S1.78
Published Online: 1992-07

©2011 by Walter de Gruyter GmbH & Co.

From the journal
Journal of Basic and Clinical Physiology and Pharmacology
Journal of Basic and Clinical Physiology and Pharmacology
Volume 3 Issue Supplement
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PREFACE
TABLE OF CONTENTS
Mechanisms for constitutive and developmental regulation of rat hepatic cytochrome P450 genes
Mechanisms of regulation of expression of hepatic cytochrome P450
Proteins involved in the regulation of the genes encoding the barbiturate-inducible P450s of rats and Bacillus megaterium
Regulation of glutathione S-transferase and quinone reductase gene expression by xenobiotics
Genetic and molecular analysis of the Ah receptor and of Cyp 1A1 gene expression
The Ah-receptor cDNA is a novel ligand activated transcription factor
Autoregulation plus negative and positive control of murine Cyp1a-1 gene expression and the [Ah]battery
Bacteria as a heterologous system for expression of steroid hydroxylases
Microsomal environment dependence of human P450 activities expressed in yeast
Expression of drug metabolizing enzymes in transgenic animals and heterologous expression systems
Stable expression of human cytochrome P450 cDNAs in human lymphoblastoid cells
Expression and characterization of human fetal liver cytochrome P450 (P450IIIA7)
The UDP-glucuronosyltransferase gene family: Function and expression of human UGTs
Structure and regulation of steroid UDP-glucuronosyltransferase genes
The novel UGT1 locus utilizes alternative transcriptional initiation and 25 differential splicing to encode human bilirubin, phenol and other UDP-glucuronosyltransferases with identical carboxyl termini
Primary structure and regulation of hepatic sulfotransferases
Regulation of gene expression of drug-metabolizing phase II enzymes
Cytochrome P450BM-3: A structural and functional model for microsomal cytochromes P450
An integrated picture of cytochrome P450 catalysis
Structure and function of the mitochondrial P450 system electron transfer proteins, adrenodoxin reductase and adrenodoxin
Correlation of the gene structures, three dimensional structures and functional properties of the glutathione S-transferases
The role of the peroxisome proliferator activated receptor in the induction of the rabbit CYP4A6 gene
Induction of P4501A1 by polycyclic aromatic compounds requires cooperation between Ah response elements and other sequence elements
Mechanisms of regulation of hormone- and substrate-dependent control of cytochrome P450 turnover
A transcription factor, Ad4BP, regulating all the steroidogenic P450 genes
The flavin-containing monooxygenase gene family
Ocular and renal cytochrome P450 arachidonic acid metabolism: Hormonal and pathological regulation
The arachidonic acid epoxygenase: A functional role for cytochrome P450 in the biosynthesis of novel lipid derived mediators
Regulation of P450-dependent hepatic steroid hydroxylation by growth hormone and thyroxine
Allene oxide synthesis: Novel reaction of cytochrome P450
Nitric oxide synthase functions as a catalytically self-sufficient cytochrome P450
Cytochrome P450lin(P450111): crystal unit cell, tertiary structure-function model
Structure and function of P450c21
Alteration of the substrate specificity of mouse 2A P450s by a mutation of residue-209: steroid-binding site and orientation
Role of the putative distal site in the catalytic function of cytochrome P4501A2
Composition of the NH2-terminal region governs the targeting of expressed P450 to Escherichia coli cytosol or membranes
Significance of phosphorylation of drug metabolizing enzymes for the control of carcinogenic metabolites
Protein adducts as index of metabolic activation and exposure to carcinogens
The role of cytochrome P4502E1 in chemically induced cytotoxicity
Metabolic activation of unsaturated derivatives of valproic acid: role of microsomal versus mitochondrial enzyme systems
Trace transition metal-catalyzed free radical reactions in microsomal drug metabolism
Genes involved in initiation and promotion in skin carcinogenesis
Genetic causes of interindividual and interethnic differences in drug metabolism
Genetic polymorphisms of drug-metabolizing enzymes in different populations
Roles in genetic polymorphisms of drug metabolizing enzymes in humans
Methyltransferase pharmacogenetics
Identification of extrahepatic drug-metabolizing enzymes and their characterization by heterologous expression in mammalian cells
Tyrphostins inhibit FSH and cAMP mediated functions in rat ovarian granulosa cells: Possible involvement of tyrosine phosphorylation
Prostate cytochrome P450
Biotransformation enzymes in olfactory signal termination
Modulation of P450 mediated estrogen metabolism by diet and its effect on hormone responsive target tissue tumors
The role of cytochrome P450 in the elimination of bilirubin in congenital jaundice (Crigler-Najjar Syndrome Type I)
Control of hyperbilirubinemia by use of heme oxygenase inhibitors
Therapeutic aspects of cytochrome P450 inhibition
Biochemistry of the steroid 5α-reductases and the physiological implications of inhibition
Common motifs in microsomal cytochrome P450 N-terminal membrane fragments
Inhibitor-induced conformational change in cytochrome P450cam
Metabolite predictions based on mechanisms of action and active site structures of cytochrome P450
Catalytic mechanisms of amine-N-dealkylation and N-oxygenation by cytochrome P450 enzymes
Modulators of stereoselective product formation in cytochrome P450cam S-oxidations
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