Copper-catalyzed Synthesis and Antimicrobial Activity of Disubstituted 1,2,3-Triazoles Starting from 1-Propargyluracils and Ethyl (4-Azido- 1,2,3-trihydroxybutyl)furan-3-carboxylate

Wael A. El-Sayed; Adel A.-H. Abdel-Rahman

doi:10.1515/znb-2010-0110

Open Access Published by De Gruyter June 2, 2014

Copper-catalyzed Synthesis and Antimicrobial Activity of Disubstituted 1,2,3-Triazoles Starting from 1-Propargyluracils and Ethyl (4-Azido- 1,2,3-trihydroxybutyl)furan-3-carboxylate

Wael A. El-Sayed and Adel A.-H. Abdel-Rahman

From the journal Zeitschrift für Naturforschung B

https://doi.org/10.1515/znb-2010-0110

1,3-Dipolar cycloaddition reactions of 1-propargyluracils 2a - h with the azido derivative 3 afforded the corresponding 1,2,3-triazoles 4a - h. Hydrazinolysis of the esters 4a - h gave the corresponding acid hydrazides 5a - h. Reaction of 5a - h with carbon disulfide in ethanol afforded 6a - h. The antimicrobial activity of compounds 4 - 6 was determined

Graphical Abstract

Copper-catalyzed Synthesis and Antimicrobial Activity of Disubstituted 1,2,3-Triazoles Starting from 1-Propargyluracils and Ethyl (4-Azido- 1,2,3-trihydroxybutyl)furan-3-carboxylate

Keywords: 1,3-Dipolar Cycloaddition; 1,2,3-Triazoles; 1,3,4-Oxadiazoles; Antimicrobial Activity

Received: 2009-8-15

Published Online: 2014-6-2

Published in Print: 2010-1-1

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Copper-catalyzed Synthesis and Antimicrobial Activity of Disubstituted 1,2,3-Triazoles Starting from 1-Propargyluracils and Ethyl (4-Azido- 1,2,3-trihydroxybutyl)furan-3-carboxylate

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