Abstract
Because of their high surface-to-volume ratio, easy surface modification, and simple synthesis methods, gold nanoparticles (AuNPs) are becoming an attractive material as an alternative to conventional solvent extraction and solid-phase extraction column for the selective extraction and enrichment of target analytes from a large sample volume. Through covalent bond formation (Au-S bonds), electrostatic attraction, hydrophobic adsorption, and molecular recognition, AuNPs have been applied successfully to the extraction/removal of a variety of compounds from biological fluids and environment waters, including thiol-containing compounds, peptides, proteins, heavy metal ions, polycyclic aromatic hydrocarbons, and melamine. This review summarizes the recent advances in properties, synthesis, and surface modification of AuNPs for the preconcentration of biomolecules and environmental pollutants.
About the authors
Jia-Hui Lin received her MS degree in analytical chemistry from National Sun Yat-sen University in 2010. She is currently a PhD student under the supervision of Prof. Wei-Lung Tseng at National Sun Yat-sen University. Her current research involves gold nanoparticles-based biosensors and nucleic acid probes.
Wei-Lung Tseng is currently an associate professor of chemistry, National Sun Yet-sen University. He received his PhD degree in analytical chemistry from National Taiwan University in 2002. His did his postdoctoral studies with Prof. Huan-Tsung Chang at National Taiwan University before joining National Sun Yet-sen University in 2005. His main research includes (1) Gold nanoparticles (AuNPs) for extraction and enrichment of target analytes; (2) Preparation and application of Au nanoclusters; (3) AuNPs for the sensing of metal ions, aminothiols, and proteins; (4) Application of AuNPs as matrices in laser desorption/ionization mass spectrometry; (5) Preparation and application of alloy semiconductor quantum dots; (6) Analysis of proteins by capillary electrophoresis; (7) Combination of capillary electrophoresis and nanoparticles.
©2012 by Walter de Gruyter Berlin Boston
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