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Licensed Unlicensed Requires Authentication Published by De Gruyter May 29, 2015

A facile, highly efficient and novel method for synthesis of 5-substituted 1H-tetrazoles catalysed by copper(I) chloride

  • İbrahim Esirden , Erhan Başar and Muharrem Kaya EMAIL logo
From the journal Chemical Papers

Abstract

The present study on tetrazole compounds, which have a wide area of application, proposes a new, simple and highly effective method. A series of 5-substituted 1H-tetrazoles were synthesised in DMF via the [3 + 2] cycloaddition reaction, in which different aryl nitriles with sodium azide were used and copper(I) chloride served as a catalyst. Short reaction times, high yields and simple procedures rendered this method attractive and useful for the organic synthesis of 5-substituted 1H-tetrazoles. A further advantage was the use of an environmentally friendly catalyst.

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Received: 2014-12-18
Revised: 2015-3-15
Accepted: 2015-3-17
Published Online: 2015-5-29
Published in Print: 2015-9-1

© Institute of Chemistry, Slovak Academy of Sciences

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