Abstract
Background: A combinatorial phage display approach was previously used to evolve a 12-mer peptide (SVSVGMKPSPRP) with the highest affinity for different semiconductor surfaces. The discovery of the multiple occurrences of the SVSVGMKPSPRP sequence in an all-against-all basic local alignment search tool search of PepBank sequences was unexpected, and a Google search using the peptide sequence recovered 58 results concerning 12 patents and 16 scientific publications. The number of patent and articles indicates that the peptide is perhaps a broad range adhesion peptide.
Methods: To evaluate peptide properties, we conducted a study to investigate peptide adhesion on different inorganic substrates by mass spectrometry and atomic force microscopy for gold, carbon nanotubes, cobalt, chrome alloy, titanium, and titanium alloy substrates.
Results: Our results showed that the peptide has a great potential as a linker to functionalize metallic surfaces if specificity is not a key factor. This peptide is not specific to a particular metal surface, but it is a good linker for the functionalization of a wide range of metallic materials.
Conclusion: The fact that this peptide has the potential to adsorb on a large set of inorganic surfaces suggests novel promising directions for further investigation. Affinity determination of SVSVGMKPSPRP peptide would be an important issue for eventual commercial uses.
We are grateful to Dr. Cristophe Goze-bac from the University Montpellier 2, France, for kindly supplying the carbon nanotube samples.
References
[1] Allemand PM, Heidecker M, Kirk G, Quan X, Wang CI. Fabrication of inorganic materials using templates with labile linkage. United States Patent 2007. WO/2007/103539.Search in Google Scholar
[2] Allemand PM, Heidecker M, Knapp MR, Nikifrorov T, Wang CI. Fluorescent particles bound to multifunctional scaffolds and their uses. United States Patent 2007. WO/2007/120762.Search in Google Scholar
[3] Arnaiz B, Madrigal-Estebas L, Todryk S, James TC, Doherty DG, Bond U. A novel method to identify and characterise peptide mimotopes of heat shock protein 70-associated antigens. J Immune Based Ther Vaccines 2006; 4: 2–14.10.1186/1476-8518-4-2Search in Google Scholar PubMed PubMed Central
[4] Atkinson H, McPherson MJ, Winter MD. Control of crop pests and animal parasites through direct neuronal uptake. Great Britain Patent 2002. WO/2002/017948.Search in Google Scholar
[5] Belcher A, Reiss B, Mao C, Solis D. Peptide mediated synthesis of metallic and magnetic materials. United States Patent 2004. WO/2004/033488.Search in Google Scholar
[6] Brett PJ, Tiwana H, Feavers IM, Charalambous BM. Characterization of oligopeptides that cross-react with carbohydrate-specific antibodies by real time kinetics, in-solution competition enzyme-linked immunosorbent assay, and immunological analyses. J Biol Chem 2002; 277: 20468–20476.10.1074/jbc.M200387200Search in Google Scholar PubMed
[7] Dai H, Pakbaz H, Spaid M, Nikiforov T. Seed layers, cap layers, and thin films and methods of making thereof. United States Patent 2006. WO/2008/013516.Search in Google Scholar
[8] Estephan E, Larroque C, Cuisinier FJC, Balint Z, Gergely C. Tailoring GaN semiconductor surfaces with biomolecules. J Phys Chem B 2008; 112: 8799–8805.10.1021/jp804112ySearch in Google Scholar PubMed
[9] Estephan E, Larroque C, Bec N, et al. Selection and mass spectrometry characterization of peptides targeting semiconductor surfaces. Biotechnol Bioeng 2009; 15: 1121–1131.10.1002/bit.22478Search in Google Scholar PubMed
[10] Fowlkes D, Kay B, Frelinger J, Hyde-Deruyscher RP. Identification of drugs using complementary combinatorial libraries. United States Patent 1998. WO/1998/019162.Search in Google Scholar
[11] Goris J, De Vos P, Caballero-Mellado J, et al. Classification of the biphenyl- and polychlorinated biphenyl-degrading strain LB400T and relatives as Burkholderia xenovorans sp. nov. Int J Syst Evol Microbiol 2004; 54: 1677.10.1099/ijs.0.63101-0Search in Google Scholar PubMed
[12] Goze Bac C, Latil S, Vaccarini L, et al. 13C NMR evidence for dynamics of nanotubes in ropes. Phys Rev B 2001; 63: 100302.10.1103/PhysRevB.63.100302Search in Google Scholar
[13] Gyuris J, Morris A. Methods and reagents for isolating biologically active peptides. United States Patent 2000. US 6,420,110.Search in Google Scholar
[14] Hou ST, Dove M, Anderson E, Zhang J, MacKenzie CR. Identification of polypeptides with selective affinity to intact mouse cerebellar granule neurons from a random peptide-presenting phage library. J Neurosci Methods 2004; 138: 39–44.10.1016/j.jneumeth.2004.03.013Search in Google Scholar PubMed
[15] Jagota A, Lustig SR, Wang S, Wang H. Carbon nanotube binding peptides. United States Patent 2003. WO/2003/102020.Search in Google Scholar
[16] Kolb G, Boiziau C. Selection by phage display of peptides targeting the HIV-1 TAR element. RNA Biol 2005; 2: 28–33.10.4161/rna.2.1.1681Search in Google Scholar PubMed
[17] Lee TY, Lin CT, Kuo SY, Chang DK, Wu HC. Peptide-mediated targeting to tumor blood vessels of lung cancer for drug delivery. Cancer Res 2007; 67: 10958–10965.10.1158/0008-5472.CAN-07-2233Search in Google Scholar PubMed
[18] Manoutcharian K, Sotelo J, Garcia E, Cano A, Gevorkian G. Characterization of cerebrospinal fluid antibody specificities in neurocysticercosis using phage display peptide library. Clin Immunol 1999; 91: 117–121.10.1006/clim.1998.4669Search in Google Scholar PubMed
[19] Mao C, Flynn CE, Hayhurst A, et al. Viral assembly of oriented quantum dot nanowires. Proc Natl Acad Sci USA 2003; 100: 6946.10.1073/pnas.0832310100Search in Google Scholar PubMed PubMed Central
[20] Messmer BT, Sullivan JJ, Chiorazzi N, Rodman TC, Thaler DS. Two human neonatal IgM antibodies encoded by different variable-region genes bind the same linear peptide: evidence for a stereotyped repertoire of epitope recognition. J Immunol 1999; 162: 2184–2192.10.4049/jimmunol.162.4.2184Search in Google Scholar
[21] Naik RR, Jones SE, Murray CJ, McAuliffe JC, Vaia RA, Stone MO. Peptide template for nanoparticle synthesis derived from polymerase chain reaction-driven phage display. Adv Funct Mater 2004; 14: 25–30.10.1002/adfm.200304501Search in Google Scholar
[22] O’Brien J, Yang PJ. Peptide based diblock and triblock dipersants and diblock polymers. United States Patent 2005. WO/2005/023836.Search in Google Scholar
[23] Pashov A, Canziani G, Macleod S, Plaxco J, Monzavi-Karbassi B, Kieber-Emmons T. Targeting carbohydrate antigens in HIV vaccine development. Vaccine 2005; 23: 2168–2175.10.1016/j.vaccine.2005.01.045Search in Google Scholar PubMed
[24] Pasquale EB, Koolpe M, Murai K. Novel agents that modulate Eph receptor activity. United States Patent 2004. WO/2004/028551.Search in Google Scholar
[25] Reiss BD, Mao C, Solis DJ, Ryan KS, Thomson T, Belcher AM. Biological routes to metal alloy ferromagnetic nanostructures. Nano Letters 2004; 4: 1127–1132.10.1021/nl049825nSearch in Google Scholar
[26] Robbins P, Mi Z, Frizzel R, Glorioso J, Gambotto A, Mai J. Identification of peptides that facilitate uptake and cytoplasmic and/or nuclear transport of proteins. United States Patent 2003. WO/2001/015511.Search in Google Scholar
[27] Roy M, Stanley S, Amis E, Becker M. Identification of a highly specific hydroxyapatite-binding peptide using phage display. Adv Mater 2008; 20: 1830–1836.10.1002/adma.200702322Search in Google Scholar
[28] Sarikaya M, Deniz S. Molecular substrates for nanobiotechnology. NNIN REU Research Accomplishments 2004; 86–87.Search in Google Scholar
[29] Sarikaya M, Tamerler C, Schwartzv DT, François B. Materials assembly and formation using engineered polypeptides. Ann Rev Mat Res 2004; 34: 373–408.10.1146/annurev.matsci.34.040203.121025Search in Google Scholar
[30] Shao R, Xiong C, Wen X, Gelovani JG, Li C. Targeting phosphatidylserine on apoptotic cells with phages and peptides selected from a bacteriophage display library. Mol Imaging 2007; 6: 417–426.10.2310/7290.2007.00037Search in Google Scholar
[31] Shtatland T, Guettler D, Kossodo M, Pivovarov M, Weissleder R. PepBank–a database of peptides based on sequence text mining and public peptide data sources. BMC Bioinformatics 2007; 8: 289–299.10.1186/1471-2105-8-280Search in Google Scholar PubMed PubMed Central
[32] So CR, Kulp JL, Oren EE, et al. Molecular recognition and supramolecular self-assembly of a genetically engineered gold binding peptide on Au[111}. ACS Nano 2009; 6: 1525–1531.Search in Google Scholar
[33] Tamerler C, Sarikaya M. Molecular biomimetics: utilizing nature’s molecular ways in practical engineering. Acta Biomater 2007; 3: 289–299.10.1016/j.actbio.2006.10.009Search in Google Scholar PubMed
[34] Van Es H, Havenga M, Verlinden S. Identification of drugs using complementary combinatorial libraries. Nederland Patent 1999. WO/1999/060147.Search in Google Scholar
[35] Verde AV, Acres JM, Maranas JK. Investigating the specificity of peptide adsorption on gold using molecular dynamics simulations. Biomacromolecules 2009; 10: 2118–2128.10.1021/bm9002464Search in Google Scholar PubMed
[36] Webb M, Ewbank G, Perkins J, McCarthy AJ. Metabolism of pentachlorophenol by the compost actinomycete, Saccharomonospora viridis. Biol Biochem 2001; 33: 1903–1914.10.1016/S0038-0717(01)00115-8Search in Google Scholar
[37] Whaley SR, English DS, Hu EL, Barbara PF, Belcher AM. Selection of peptides with semiconductor binding specificity for directed nanocrystal assembly. Nature 2000; 405: 665–668.10.1038/35015043Search in Google Scholar
[38] Wiesehan K, Buder K, Linke RP, et al. Selection of d-amino-acid peptides that bind to Alzheimer’s disease amyloid peptide abeta1–42 by mirror image phage display. Chembiochem 2003; 4: 748–753.10.1002/cbic.200300631Search in Google Scholar
[39] Wolcke J, Weinhold E. A DNA-binding peptide from a phage display library. Nucleosides Nucleotides Nucleic Acids 2001; 20: 1239–1241.10.1081/NCN-100002526Search in Google Scholar
[40] Wu SC, Lin CW. Neutralizing peptide ligands selected from phage-displayed libraries mimic the conformational epitope on domain III of the Japanese encephalitis virus envelope protein. Virus Res 2001; 76: 59–69.10.1016/S0168-1702(01)00246-5Search in Google Scholar
[41] Wu HC, Lin CT, Chang DK. Lung cancer-targeted peptides and applications thereof. 2008. PCT WO/2008/100481.Search in Google Scholar
[42] Wu HC, Lin CT, Lee TY, Kuo SY. Peptides that target to tumor blood vessels of lung cancer and applications thereof. 2008. PCT WO/2008/100482.Search in Google Scholar
[43] Yang B, Gao L, Li L, et al. Potent suppression of viral infectivity by the peptides that inhibit multimerization of human immunodeficiency virus type 1 (HIV-1) Vif proteins. J Biol Chem 2003; 278: 6596–6602.10.1074/jbc.M210164200Search in Google Scholar PubMed PubMed Central
[44] Zhang H, Pomerantz R, Yang B. Multimerization of HIV-1 Vif protein as a therapeutic target. United States Patent 2002. WO/2002/081504.Search in Google Scholar
[45] Zheng L, Jain D, Burke P. Nanotube —peptide interactions on a silicon chip. J Phys Chem C 2009; 113: 3978–3985.10.1021/jp809370zSearch in Google Scholar
©2012 by Walter de Gruyter Berlin Boston
