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Licensed Unlicensed Requires Authentication Published by De Gruyter 2023

8 Synthesis, characterization and in vitro activity study of some organotin(IV) carboxylates against leukemia cancer cell, L-1210

From the book Sustainable Chemistry Research

  • Sutopo Hadi , Ermin Katrin Winarno , Hendig Winarno , Khairun Nisa Berawi , Tati Suhartati , Yandri Yandri and Wasinton Simanjuntak
https://doi.org/10.1515/9783111071435-008

Abstract

This paper presents successful resynthesizing of several dibutyl-, diphenyl-, and triphenyltin(IV) carboxylate compounds, and their activity against leukemia cancer cell, L-1210. The compounds were synthesized by reacting the dibutyltin(IV) oxide (DBTO) (1), diphenyltin(IV) oxide (DPTO) (3), and triphenyltin(IV) hydroxide (TPTOH) (5) with 3-hydroxybenzoic acid (3-HHBz). Prior to cancer activity tests, the compounds were characterized by UV-Vis, FT-IR, NMR (both 1H NMR and 13C NMR), and microanalysis to determine elemental composition of the samples. The anticancer tests revealed that triphenyltin(IV) 3-hydroxybenzoate (TPTHBz) (6) displayed significantly higher activity than those exhibited by dibutyltin(IV) di(3-hydroxybenzoate) (DBTHBz) (2) and diphenyltin( IV) di(3-hydroxybenzoate) (DPTHBz) (4).

© 2023 Walter de Gruyter GmbH, Berlin/Boston
From the book
Sustainable Chemistry Research
Sustainable Chemistry Research

Chapters in this book (24)

Frontmatter
Preface of the Book of Proceedings of the Virtual Conference on Chemistry and its Applications (VCCA-2022).
Contents
List of contributing authors
1 Dipeptidyl peptidase IV: a multifunctional enzyme with implications in several pathologies including cancer
2 A mini review on the prospects of Fagara zanthoxyloides extract based composites: a remedy for COVID-19 and associated replica?
3 Triterpenoids of antibacterial extracts from the leaves of Bersama abyssinica Fresen (Francoaceae)
4 Physicochemical assessment and insilico studies on the interaction of 5-HT2c receptor with herbal medication bioactive compounds used in the treatment of premature ejaculation
5 Xanthoangelol, geranilated chalcone compound, isolation from pudau leaves (Artocarpus kemando Miq.) as antibacterial and anticancer
6 Exploration of bioactive compounds from Mangifera indica (Mango) as probable inhibitors of thymidylate synthase and nuclear factor kappa-B (NF-Κb) in colorectal cancer management
7 Identification of potential inhibitors of thymidylate synthase (TS) (PDB ID: 6QXH) and nuclear factor kappa-B (NF–κB) (PDB ID: 1A3Q) from Capsicum annuum (bell pepper) towards the development of new therapeutic drugs against colorectal cancer (CRC)
8 Synthesis, characterization and in vitro activity study of some organotin(IV) carboxylates against leukemia cancer cell, L-1210
9 Phytochemicals from Annona muricata (Sour Sop) as potential inhibitors of SARS-CoV-2 main protease (Mpro) and spike receptor protein: a structure-based drug design studies and chemoinformatics analyses
10 Identification of novel inhibitors of P13K/AKT pathways: an integrated in-silico study towards the development of a new therapeutic agent against ovarian cancer
11 Immobilization of α-amylase from Aspergillus fumigatus using adsorption method onto zeolite
12 Phytochemical components and GC–MS analysis of Petiveria alliaceae L. fractions and volatile oils
13 Characterization of crude saponins from stem bark extract of Parinari curatellifolia and evaluation of its antioxidant and antibacterial activities
14 Physicochemical and free radical scavenging activity of Adansonia digitata seed oil
15 Photoprotection strategies with antioxidant extracts: a new vision
16 A systematic DFT study of arsenic doped iron cluster AsFen (n = 1–4)
17 Effect of case-based learning, team-based learning and regular teaching methods on secondary school students’ self-concept in chemistry in Maara sub-county, Tharaka Nithi county, Kenya
18 Random and block architectures of N-arylitaconimide monomers with methyl methacrylate
19 Evaluation of phytochemicals and amino acid profiles of four vegetables grown on a glyphosate contaminated soil in Southwestern Nigeria
Index
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