Theories of Population Variation in Genes and Genomes

Freddy Bugge Christiansen

Published by Princeton University Press 2008

Theories of Population Variation in Genes and Genomes

Freddy Bugge Christiansen

Volume 4 in the series Princeton Series in Theoretical and Computational Biology

https://doi.org/10.1515/9781400866656

Overview
Contents

About this book

This textbook provides an authoritative introduction to both classical and coalescent approaches to population genetics. Written for graduate students and advanced undergraduates by one of the world's leading authorities in the field, the book focuses on the theoretical background of population genetics, while emphasizing the close interplay between theory and empiricism. Traditional topics such as genetic and phenotypic variation, mutation, migration, and linkage are covered and advanced by contemporary coalescent theory, which describes the genealogy of genes in a population, ultimately connecting them to a single common ancestor. Effects of selection, particularly genomic effects, are discussed with reference to molecular genetic variation. The book is designed for students of population genetics, bioinformatics, evolutionary biology, molecular evolution, and theoretical biology--as well as biologists, molecular biologists, breeders, biomathematicians, and biostatisticians.

Contains up-to-date treatment of key areas in classical and modern theoretical population genetics

Provides in-depth coverage of coalescent theory

Discusses genomic effects of selection

Gives examples from empirical population genetics

Incorporates figures, diagrams, and boxed features throughout

Includes end-of-chapter exercises

Speaks to a wide range of students in biology, bioinformatics, and biostatistics

Author / Editor information

Freddy Bugge Christiansen is professor of population biology at the University of Aarhus in Denmark. He is the author of Population Genetics of Multiple Loci and coauthor of Theories of Populations in Biological Communities and Population Genetics.

Reviews

I applaud the primary goal of this book, that is, to present basic genetic and population genetic concepts to future researchers in genomics and bioinformatics. I think that understanding the core evolutionary framework is essential for successful analysis and interpretation of contemporary genetic data.---Phil Hedrick, Journal of Heredity

This very well-written book is challenging, but rewarding. Motivated readers will understand the dynamic nature of genetic variation in populations.---Richard M. Kijman, Quarterly Review of Biology

Topics

Frontmatter Publicly Available Download PDF	i
Contents Publicly Available Download PDF	v
Preface and Acknowledgments Requires Authentication Unlicensed Licensed Download PDF	ix
Introduction Requires Authentication Unlicensed Licensed Download PDF	1
Part I. Genetic Variation
1. Genetics Requires Authentication Unlicensed Licensed Download PDF	5
2. Conservation of Variation Requires Authentication Unlicensed Licensed Download PDF	21
3. Diploid Populations Requires Authentication Unlicensed Licensed Download PDF	53
4. Mutation and Variation Requires Authentication Unlicensed Licensed Download PDF	71
5. Migration Requires Authentication Unlicensed Licensed Download PDF	108
6. Linkage Requires Authentication Unlicensed Licensed Download PDF	139
7. Phenotypic Variation Requires Authentication Unlicensed Licensed Download PDF	181
Part II. Variation and Selection
8. Effects of Selection Requires Authentication Unlicensed Licensed Download PDF	213
9. Genomic Effects of Selection Requires Authentication Unlicensed Licensed Download PDF	264
10. Population Structure Requires Authentication Unlicensed Licensed Download PDF	309
A. Probability Theory and Statistics Requires Authentication Unlicensed Licensed Download PDF	345
B. Solutions to Exercises Requires Authentication Unlicensed Licensed Download PDF	363
Bibliography Requires Authentication Unlicensed Licensed Download PDF	383
Index Requires Authentication Unlicensed Licensed Download PDF	413