Endocrine Journal
Online ISSN : 1348-4540
Print ISSN : 0918-8959
ISSN-L : 0918-8959
ORIGINALS
Regulation of Adiponectin Receptor 2 Expression via PPAR-α in NIT-1 Cells
Tae Woo JUNG, Myung Won LEE, Yong Jik LEE, Seon Mee KIM, Kyoung Tae LEE, Wan Kyunn WHANG, Hwan Ju CHEON, Yeon Taek JEONG, Kun Wook CHUNG, Jae Min CHO, Do Hoon KIM, Tae Woo JUNG
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Keywords: Adiponectin receptor 2, peroxisome proliferator-activated receptor-alpha, β cells, Clofibrate, palmitate
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2009 Volume 56 Issue 3 Pages 377-382

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Abstract

Adiponectin receptors mediate the antidiabetic effects of adiponectin. Although suggested to be mainly expressed in muscle, liver, and adipocyte cells, the expression of adiponectin receptors in β cells is unclear. Given the primary involvement of this cell type in diabetes mellitus, we presently examined the expression level of adiponectin receptor 2 (AdiR2) in β cells. Expression was significantly increased under acute hyperlipidemic conditions but impaired under chronic conditions. The impaired AdiR2 expression may play a role in worsened β cell function. Clofibrate, an agonist of peroxisome proliferator-activated receptor-alpha (PPAR-α) delayed the palmitate-induced impairment of AdiR2 expression and PPAR-α; this delay was abolished by PPAR-α targeted small interfering RNA. The results suggest that AdiR2 expression is regulated by palmit ate via PPAR-α.

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