No Ghrelin Response to Oral Glucose in Diabetes Mellitus with Gastroparesis

Shiko ASAI; Takuyuki KATABAMI; Naoko OBI; Tomoya MATSUI; Hiroyuki KATO; Ryusei OBI; Yutaka OGAWA; Takehiro KAWATA; Haruyuki TAKAMA; Akio OHTA; Yasushi TANAKA

doi:10.1507/endocrj.K08E-169

ORIGINALS

No Ghrelin Response to Oral Glucose in Diabetes Mellitus with Gastroparesis

Shiko ASAI, Takuyuki KATABAMI, Naoko OBI, Tomoya MATSUI, Hiroyuki KATO, Ryusei OBI, Yutaka OGAWA, Takehiro KAWATA, Haruyuki TAKAMA, Akio OHTA, Yasushi TANAKA

Author information

Shiko ASAI
Department of Internal Medicine, Division of Metabolism and Endocrinology, St. Marianna University School of Medicine
Takuyuki KATABAMI
Department of Internal Medicine, Division of Metabolism and Endocrinology, St. Marianna University School of Medicine
Naoko OBI
Department of Internal Medicine, Division of Metabolism and Endocrinology, St. Marianna University School of Medicine
Tomoya MATSUI
Department of Internal Medicine, Division of Metabolism and Endocrinology, St. Marianna University School of Medicine
Hiroyuki KATO
Department of Internal Medicine, Division of Metabolism and Endocrinology, St. Marianna University School of Medicine
Ryusei OBI
Department of Internal Medicine, Division of Metabolism and Endocrinology, St. Marianna University School of Medicine
Yutaka OGAWA
Department of Internal Medicine, Division of Metabolism and Endocrinology, St. Marianna University School of Medicine
Takehiro KAWATA
Department of Internal Medicine, Division of Metabolism and Endocrinology, St. Marianna University School of Medicine
Haruyuki TAKAMA
Department of Internal Medicine, Division of Metabolism and Endocrinology, St. Marianna University School of Medicine
Akio OHTA
Department of Internal Medicine, Division of Metabolism and Endocrinology, St. Marianna University School of Medicine
Yasushi TANAKA
Department of Internal Medicine, Division of Metabolism and Endocrinology, St. Marianna University School of Medicine

Keywords: Ghrelin, Diabetic gastroparesis, Cardiac autonomic neuropathy, ¹³C-acetate breath test, Coefficient of variation of the R-R interval

JOURNAL FREE ACCESS

2009 Volume 56 Issue 1 Pages 79-87

DOI https://doi.org/10.1507/endocrj.K08E-169

View "Advance Publication" version (October 22, 2008).

Details

Abstract

To investigate the role of ghrelin, an endogenous ligand of the growth hormone secretagogue receptor, in diabetic gastroparesis, we evaluated the plasma ghrelin profile during the oral glucose tolerance test in 55 patients with diabetes (men/women: 36/19, mean ± SE of age: 55.1 ± 1.7 years) with or without gastroparesis (diagnosed by the ¹³C-acetate breath test). We also further examined cardiac autonomic neuropathy by assessing 24-hour variation of the R-R interval in randomly selected 32 patients with diabetes (men/women: 23/9, mean ± SE of age: 54.2 ± 2.5 years), and evaluated the influence of autonomic neuropathy on ghrelin. The fasting plasma ghrelin level was significantly lower in diabetes mellitus with gastroparesis than in healthy controls (7.9 ± 0.7 fmol/ml versus 16.6 ± 5.3 fmol/ml, p = 0.006). Patients with diabetes with gastroparesis showed no decrease of plasma ghrelin after glucose loading, unlike patients without gastroparesis or healthy controls. Diabetes mellitus with autonomic neuropathy, but not those without it, also showed no decrease of plasma ghrelin after glucose loading. Diabetic gastroparesis may be related to ghrelin-associated neurohormonal abnormalities, but the pathophysiological meaning of this abnormal ghrelin response needs further clarification.

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