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タイトル: | 下大静脈腫瘍塞栓を伴う腎細胞癌に対し外科的切除を行った症例の治療成績 |
その他のタイトル: | Clinical Outcome of Surgical Resection for Renal Cell Carcinoma with Inferior Vena Cava Tumor Thrombus |
著者: | 中西, 裕美 大庭, 康司郎 中村, 裕一郎 安田, 拓司 光成, 健輔 松尾, 朋博 望月, 保志 宮田, 康好 |
著者名の別形: | NAKANISHI, Hiromi OHBA, Kojiro NAKAMURA, Yuichiro YASUDA, Takuji MITSUNARI, Kensuke MATSUO, Tomohiro MOCHIZUKI, Yasushi MIYATA, Yasuyoshi |
キーワード: | Renal cell carcinoma with inferior vena cava tumor embolism Nephrorectomy Metastatic renal cell carcinoma Immune checkpoint inhibitors |
発行日: | 31-Aug-2023 |
出版者: | 泌尿器科紀要刊行会 |
誌名: | 泌尿器科紀要 |
巻: | 69 |
号: | 8 |
開始ページ: | 207 |
終了ページ: | 214 |
抄録: | We analyzed 45 patients who were diagnosed with renal cell carcinoma with inferior vena cava tumor thrombus (IVC) and underwent surgical resection at Nagasaki University Hospital during the 17 years from March 2003 to November 2020. The median overall survival (OS) was 68.5, 53.5, 45.7, and 20.4 months, respectively, according to the tumor thrombus level (Lv) of I, II, III and IV, with a median level of (P=0.025). In multivariate analysis, pathological sarcomatoid changes were associated with risk of tumor recurrence in the postoperative complete remission group, and IVC thrombus level above Lv III was associated with poor prognosis in the postoperative incomplete remission group. On postoperative systemic treatment for the postoperative recurrence group and the incomplete remission group, overall survival was significantly prolonged in cases using immune checkpoint inhibitors. The results of surgical treatment of renal cell carcinoma with IVC tumor embolization were analyzed. Patients who underwent surgical resection and achieved postoperative complete remission had a relatively long prognosis with a median OS of more than 6 years. In contrast, patients with metastases, especially those with postoperative incomplete remission group, had a poor prognosis despite surgical resection, depending on the patient's situation. |
著作権等: | 許諾条件により本文は2024-09-01に公開 |
DOI: | 10.14989/ActaUrolJap_69_8_207 |
URI: | http://hdl.handle.net/2433/284935 |
PubMed ID: | 37667597 |
出現コレクション: | Vol.69 No.8 |
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