Review Articles
Therapeutic Transdifferentiation: Can we Generate Cardiac Tissue Rather Than Scar after Myocardial Injury?
Authors:
- Nazish SayedEmail Nazish Sayed
- Wing Tak Wong
- John P. Cooke
Abstract
After myocardial injury, the cardiac muscle does not regenerate and heals by forming a scar. This process results in loss of heart function and ultimately heart failure. Recent application of reprogramming technology, where forced expression of master regulators convert scar-forming cells to become cardiovascular cells in vivo, has fueled new hope for the development of therapies targeting heart disease.
- Year: 2013
- Volume: 9 Issue: 4
- Page/Article: 210-212
- DOI: 10.14797/mdcj-9-4-210
- Published on 1 Oct 2013
- Peer Reviewed