Histol Histopathol

Original Article Open Access

High Annexin A10 expression is correlated with poor prognosis in pancreatic ductal adenocarcinoma

Akira Ishikawa1, Kazuya Kuraoka1,2, Junichi Zaitsu2, Akihisa Saito2, Atsushi Yamaguchi3, Toshio Kuwai3, Takeshi Sudo4, Naoto Hadano4, Hirotaka Tashiro4, Kiyomi Taniyama5 and Wataru Yasui6

1Institute for Clinical Laboratory, 2Department of Diagnostic Pathology, 3Department of Gastroenterology, 4Department of Surgery, 5Honorary President, National Hospital Organization, Kure Medical Center and Chugoku Cancer Center, Aoyama, Kure and 6Department of Molecular Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Kasumi, Minami-ku, Hiroshima, Japan


Corresponding Author: Kazuya Kuraoka, Department of Diagnostic Pathology, National Hospital Organization, Kure Medical Center and Chugoku Cancer Center, 3-1 Aoyama, Kure 737-0023, Japan. e-mail: kuraoka.kazuya.vk@mail.hosp.go.jp


Summary. Pancreatic ductal adenocarcinoma (PDAC) is the third-leading cause of cancer-related death. Owing to its poor prognosis, new molecular biomarkers for PDAC are needed. Annexin A10 (ANXA10) is a calcium-/phospholipid-binding protein belonging to the annexin family of proteins. ANXA10 is not only associated with gastric phenotypes, but also acts an independent prognostic factor in several cancers. However, the role of ANXA10 in PDAC remains unknown. Therefore, we examined the relationship between ANXA10 and the prognosis of PDAC. We analyzed the expression of ANXA10 using data from public databases, and performed immunohistochemistry analysis for 81 PDAC cases. We then investigated the relationship between ANXA10 expression and clinicopathological features. ANXA10 was detected in 47 of 81 PDAC cases (58%). High expression of ANXA10 was significantly related to poor overall survival (OS; p=0.011). Univariate analysis of OS revealed three prognostic parameters: tumor grade (p=0.046), perineural invasion (p=0.017), and ANXA10 expression (p=0.012). Multivariate analysis indicated that ANXA10 expression (p<0.01) alone was a prognostic factor in PDAC cases. Our findings suggest that ANXA10 expression is an independent prognostic factor in PDAC cases and shows promise as a new biomarker in PDAC. Histol Histopathol 37, 243-250 (2022)

Key words: Annexin A10, Pancreatic cancer, Biomarker

DOI: 10.14670/HH-18-397

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