Metastasis suppressor genes
Jinchun Yan1,2, Qin Yang2 and Qihong Huang3
1University of Washington Medical Center, Seattle, USA, 2Department of Radiation Oncology, Washington University School of Medicine, Saint Louis, MO, USA and 3The Wistar Institute, USA.
Offprint requests to: Jinchun Yan, University of Washington Medical Center, 1959 N. E. Pacific Street, Seattle, WA 98195, USA. e-mail: jyan@u.washington.edu, or Qihong Huang, The Wistar Institute, 3601 Spruce Street, PA 19104, USA. e-mail: qhuang@wistar.org
Summary. Metastasis is a major cause of cancer mortality. Metastasis is a complex process that requires the regulation of both metastasis-promoting and metastasis suppressor genes. The discovery of metastasis suppressor genes contributes significantly to our understanding of metastasis mechanisms and provides prognostic markers and therapeutic targets in clinical cancer management. In this review, we summarize the methods that have been used to identify metastasis suppressors and the potential clinical impact of these genes. Histol Histopathol 28, 285-292 (2013)
Key words: Metastasis, Metastasis suppressor, RNA interference, Functional genomics, Next generation sequencing
DOI: 10.14670/HH-28.285