Up-regulation of CMKLR1 in endometriosis and its relationship with inflammatory responses
Zhe Zhang1, Yumei Ding1, Junjie Li2 and Shan Su1
1Department of Gynecology and 2Department of Anesthesiology, Zibo Central Hospital, Zibo, Shandong, China
Corresponding Author: Junjie Li, Department of Anesthesiology, Zibo Central Hospital, No. 54 Gongqingtuan West Road, Zibo 255036, Shandong, China. e-mail: lijunjie19860527@126.com
Summary. Inflammation plays a critical role in the pathogenesis of endometriosis. We aimed to study the proinflammatory effect of Chemerin chemokine-like receptor 1 (CMKLR1) in patients with endometriosis. Sixty patients with endometriosis and 50 healthy controls were recruited in this study for the collection of endometrial samples and peritoneal fluid. The expression levels of CMKLR1, IL-6, MCP-1, and TNF-α in peritoneal fluid and endometrial tissues were detected by ELISA, qRT-PCR, and immunohisto-chemical staining. Human endometrial stromal cells (HESCs) were used to measure the Chemerin-induced CMKLR1 activation and inflammatory responses. CMKLR1 level was significantly up-regulated in peritoneal fluid and endometrial tissues in patients with endometriosis. Interestingly, CMKLR1 overexpression positively correlated with pro-inflammatory cytokines and chemokine in both peritoneal fluid and ectopic endometrium. Chemerin treatment increased the expression of CMKLR1, and aggravated inflammatory responses in HESCs. CMKLR1 is up-regulated in peritoneal fluid and endometrial tissues, and promotes the inflammatory responses in of endometriosis. Histol Histopathol 38, 329-337 (2023)
Key words: CMKLR1, Endometriosis, Inflammatory responses, Chemerin
DOI: 10.14670/HH-18-523
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ŠThe Author(s) 2023. Open Access. This article is licensed under a Creative Commons CC-BY International License. |
