Prognostic significance of E-cadherin,
β-catenin and cyclin D1 in oral squamous cell carcinoma: a tissue microarray study
Natheer Al-Rawi1, Muwaffaq Al Ani2, Asif Quadri3, Zaid Hamdoon1, Aktham Awwad4, Sausan Al Kawas1 and, Ahmed Al Nuaimi5
1Department of Oral and Craniofacial Health Sciences, College of Dental Medicine, University of Sharjah, 2ENT Department, Tawam Hospital, Al-Ain, 3Department of Anatomic Pathology, National Reference lab. Abu Dhabi, 4Department of Histopathology, Tawam hospital, Al-Ain, United Arab Emirates and 5Primary Health Care Corporation (PHCC), Doha, Qatar
Corresponding Author: Prof. Natheer H. Al-Rawi (PhD), Department Oral and Craniofacial Health Sciences, College of Dental Medicine, University of Sharjah, Sharjah, United Arab Emirates. e-mail: nhabdulla@sharjah.ac.ae
Summary. Objective. To study the prognostic significance of E-cadherin, β-catenin, and cyclin D1 expression in oral squamous cell carcinoma.
Subjects and Methods. The study included 65 subjects with histologically confirmed squamous cell carcinoma. TMA blocks were prepared for immunohistochemical quantification of the expression of the three markers using IHC profiler and Immune ratio plugin of Image J.
Results. E-cadherin expression was significantly correlated with histological grades and the metastasis status (p<0.05), whereas β-catenin expression was significantly correlated with smoking and tumor recurrence (P<0.05). Cyclin D1 expression was significantly correlated with depth of invasion and tumor recurrence. (p<0.05). Advanced tumor stage and depth of tumor invasion increases the risk of recurrence or death by 2.5 times (OR=2.53 and 0.84 respectively).
Conclusion. High expression of β-catenin and cyclin D1 are significantly correlated with tumor recurrence and old age. Depth of invasion, low histological grade and old age were a significant predictor for the risk of having tumor recurrence and cancer related death. Histol Histopathol 36, 1073-1083 (2021)
Key words: E-cadherin, β-catenin, Cyclin D, OSCC, Cell adhesion
DOI: 10.14670/HH-18-363
 |
©The Author(s) 2021. Open Access. This article is licensed under a Creative Commons CC-BY International License. |
