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https://doi.org/10.14300/mnnc.2021.16042

Influence of D-asparagine on the engraftment of a biopolymer scaffold for replacing skin defects

[Experimental medicine]
Azamat Kade; Artem Ivanovich Trofimenko; Sergey Borisovich Bogdanov; Yulia Valentinovna Galushko; Sabina Muratovna Zench;

The influence of D-asparagine on the engraftment of a biopolymer scaffold, the main components of which were sodium alginate and gelatin, for replacing skin defects after necrectomy of burn wounds was investigated in an experimental rat model. The results of morphometric and fractal analyses of histological micro-preparations showed that the inclusion of D-asparagine in the composition of the scaffold had a positive effect on its engraftment and remodeling on day 30 after implantation. The study showed that the proposed scaffold is a promising material for replacing the skin in burn wounds.

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Keywords: D-asparagine, biopolymer scaffold, skin, burn, fractal analysis