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Specialized neurocritical care, severity grade, and outcome of patients with aneurysman subarachnoid hemorrhage

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Abstract

Introduction

To evaluate the impact of specialized neurocritical care on the population admitted to a neurovascular center and on the outcome of patients with severe aneurysmal subarachnoid hemorrhage (aSAH).

Methods

After exclusion of patients treated with endovascular techniques, between 1999 and 2003, 198 patients with aSAH treated with early aneurysm clipping were analysed. In 1999, a new standardized protocol for intensive care treatment was established in the Department of Neurosurgery, University Hospital Zurich. The results were compared to the earlier time period (1993–1994) immediately after introduction of early aneurysm clipping.

Results

Out of 198 patients with aSAH, 90 patients (45.5%) suffered from mild aSAH World Federation of Neurosurgical Societies (WFNS) grade 1 and 2, 41 (27.3%) from aSAH WFNS grade 3, 36 (18.2%) from grade 4, and 57 (28.8%) from grade 5. From 1999 to 2003, significantly more patients with severe aSAH WFNS grade 4 and 5 underwent (further) treatment (93 out of 198 patients; 47.0%) compared to the former time-period after introduction of early surgery (23 out of 150 patients; 15.3%) (p<0.0001). In the early series, 10 out of 23 patients (43.5%) with WFNS 4 recovered with good outcome Glasgow Outcome Score 4 and 5, whereas in the later series 23 out of 36 (63.9%) with WFNS grade 4 survived in a good functional state. Before 1999, all patients with WFNS grade 5 died or survived in a vegetative state. From 1999 to 2003, 20 out of 57 patients (35.1%) with aSAH WFNS grade 5 survived with good outcome.

Conclusions

The availability of extended specialized neurocritical care seems to induce a change within the patient population towards a higher severity grade. Patients with high-grade aSAH might benefit most from highly specialized neurocritical care treatment.

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Authors and Affiliations

  1. Neurocritical Care Unit, Department of Neurosurgery, University Hospital, C Nord 1 Frauenklinikstrasse 10, CH-8091, Zurich, Switzerland

    Corinne Lerch, Yasuhiro Yonekawa, Carl Murol, Miroslava Bjeljac & Emanuela Keller

Authors
  1. Corinne Lerch
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  2. Yasuhiro Yonekawa
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  3. Carl Murol
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  4. Miroslava Bjeljac
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  5. Emanuela Keller
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Correspondence to Emanuela Keller.

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Lerch, C., Yonekawa, Y., Murol, C. et al. Specialized neurocritical care, severity grade, and outcome of patients with aneurysman subarachnoid hemorrhage. Neurocrit Care 5, 85–92 (2006). https://doi.org/10.1385/NCC:5:2:85

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