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Heparanase, galectin-3, and tissue factor mRNA are expressed in benign neoplasms of the thyroid

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Abstract

Objective: Heparanase, galectin-3, and tissue factor (TF) are overexpressed in solid malignant thyroid tumors. We studied their expression in multinodular goiters (MNGs).

Design and Methods: Thyroid tissue specimens from 15 MNGs were obtained during surgery. mRNA expression for galectin-3, heparanase, and TF was assessed by RT-PCR.

Results: Isolated expressions of heparanase and galectin-3 mRNA were expressed in 2 and 4 of the 15 MNGs, respectively; 8/15 MNGs were positive for both heparanase and galectin-3. TF mRNA was found in all MNG specimens.

Conclusion: Galectin-3, heparanase, and TF RNA expression is prevalent in MNGs. Further studies will be needed to determine the prognostic significance of these findings.

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Authors and Affiliations

  1. Didbetes Unit and Internal Medicine “C”, University Hospital Hadassah, Jerusalem, Israel

    Andreas E. Buchs, Osnat Sher & Micha J. Rapoport

  2. Department of Pathology, University Hospital Hadassah, Jerusalem, Israel

    Sergei Zehavi

  3. Department of Ear Nose and Throat Assaf Harofeh Medical Center, Zerifin, Israel

    Eyal Yeheskely

  4. the Tel Aviv University, Israel

    Eyal Yeheskely

  5. Department of Surgery, University Hospital Hadassah, Jerusalem, Israel

    Michael Muggia-Sulam

  6. Department of Pathology, University Hospital Hadassah, Jerusalem, Israel

    Yoav Sherman

Authors
  1. Andreas E. Buchs
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  2. Sergei Zehavi
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  3. Osnat Sher
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  4. Eyal Yeheskely
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  5. Michael Muggia-Sulam
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  6. Yoav Sherman
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  7. Micha J. Rapoport
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Correspondence to Andreas E. Buchs.

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Buchs, A.E., Zehavi, S., Sher, O. et al. Heparanase, galectin-3, and tissue factor mRNA are expressed in benign neoplasms of the thyroid. Endocr 22, 81–83 (2003). https://doi.org/10.1385/ENDO:22:2:81

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  • DOI: https://doi.org/10.1385/ENDO:22:2:81

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