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Evaluation of insulin sensitivity in patients with Klinefelter’s syndrome

A hyperinsulinemic euglycemic clamp study

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Abstract

Patients with Klinefelter’s syndrome have a higher incidence of diabetes mellitus and the percentage of insulin resistance was reported to be high in these patients. However, little is known about the insulin sensitivity assessed by the hyperinsulinemic euglycemic clamp in these patients. In the present study, subjects included 13 newly diagnosed patients with Klinefelter’s syndrome, and 9 age- and body mass index-matched healthy males. The hyperinsulinemic euglycemic clamp was performed in all patients and controls. Insulin resistance was present in five (38.5%) patients with Klinefelter’s syndrome. Compared with control subjects, patients with Klinefelter’s syndrome had elevated plasma concentrations of fasting insulin, follicle-stimulating hormone, luteinizing hormone, estradiol, and sex hormone-binding globulin, whereas they had reduced plasma free testosterone and total testosterone concentrations. The multivariate linear regression analysis showed that fasting glucose, fasting insulin, free testosterone, and total testosterone were independently associated with M-value. In conclusion, the present study by using hyperinsulinemic euglycemic clamp indicates the high prevalence of insulin resistance in Klinefelter’s syndrome patients. However, these patients did not have reduced mean M-values compared with the controls, although their plasma insulin levels were significantly elevated. It is possible that hyperinsulinemia may be the primary metabolic abnormality rather than insulin resistance.

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Author information

Authors and Affiliations

  1. Department of Gastroenterology, Gülhane Military Medical Academy, Ankara, Turkey

    Zeki Yesilova & Kemal Dagalp

  2. Department of Biostatistics, Gülhane Military Medical Academy, Ankara, Turkey

    S. Yavuz Sanisoglu

  3. Department of Immunology, Gülhane Military Medical Academy, Ankara, Turkey

    Ugur Musabak

  4. Department of Biochemistry, Gülhane Military Medical Academy, Ankara, Turkey

    Erdinc Cakir

  5. Department of Endocrinology and Metabolism, Gülhane Military Medical Academy, Ankara, Turkey

    Metin Ozata

  6. Dept. of Internal Medicine, Gülhane Military Medical Academy, PR-06018, Etlik-Ankara, Turkey

    Cagatay Oktenli (Assoc. Prof. of Medicine)

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  1. Zeki Yesilova
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  2. Cagatay Oktenli
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  3. S. Yavuz Sanisoglu
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  7. Kemal Dagalp
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Correspondence to Cagatay Oktenli.

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Yesilova, Z., Oktenli, C., Sanisoglu, S.Y. et al. Evaluation of insulin sensitivity in patients with Klinefelter’s syndrome. Endocr 27, 11–15 (2005). https://doi.org/10.1385/ENDO:27:1:011

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  • DOI: https://doi.org/10.1385/ENDO:27:1:011

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