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Reelin signaling and Cdk5 in the control of neuronal positioning

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Abstract

Neuronal positioning is important for higher brain function because it is the architectural basis of the formation of precise synaptic circuits. Analysis of neurological mutant mice has led to dramatic progress in the identification and characterization of molecules important for neuronal positioning in the developing mammalian brain. Among these molecules, identification of signal pathways mediated by Reelin and Cdk5 kinase has provided a conceptual framework for exploring the molecular mechanisms underlying proper neuronal positioning in the developing mammalian brain. Recent evidence has implicated synergism between Reelin signaling and Cdk5 in contributing to the proper positioning of selective neuronal populations.

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  1. Laboratory for Developmental Neurobiology, Brain Science Institute, The Institute of Physical and Chemical Research (RIKEN), Wako, 351-0198, Saitama, Japan

    Toshio Ohshima & Katsuhiko Mikoshiba

  2. Division of Molecular Neurobiology, Department of Basic Medical Science, The Institute of Medical Science, The University of Tokyo, Minato-ku, 108-8639, Tokyo, Japan

    Katsuhiko Mikoshiba

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  1. Toshio Ohshima
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Correspondence to Toshio Ohshima.

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Ohshima, T., Mikoshiba, K. Reelin signaling and Cdk5 in the control of neuronal positioning. Mol Neurobiol 26, 153–166 (2002). https://doi.org/10.1385/MN:26:2-3:153

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