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Fetal and neonatal exposure to nicotine disrupts ovarian function and fertility in adult female rats

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Abstract

Women born to mothers who smoked during pregnancy have been shown to have imparied fertility, although the mechanisms underlying this association are unknown. Nicotine administration in adult animals has adverse effects on the ovary and uterus; however, the effects of fetal exposure to nicotine on postnatal ovarian function have not been determined. The goal of this study was to assess the effect of fetal and neonatal exposure to nicotine on ovarian function and fertility of the offspring. Nulliparous female Wistar rats were given 1 mg·kg−1·d−1 nicotine bitartrate, subcutaneously for 14 d prior to mating, during pregnancy and throughout lactation until weaning. Measures of fertility, breeding success, and serum levels of ovarian steroid hormones in offspring were assessed at 4 and 6 mo of age. Fetal and neonatal exposure to nicotine significantly increased the time to pregnancy as the animals aged. Similarly, evidence of altered ovarian steroidogenesis in cluding increased serum progesterone concentrations and a decreased estrogen: progesterone ratio was observed in 6-mo-old animals. We conclude that fetal and neonatal exposure to nicotine results in delayed ovarian dysfunction in adult female offspring.

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References

  1. Norgil Damgaard, I., Main, K. M., Toppari, J., and Skakkebaek, N. E. (2002). Best Pract. Res. Endocrinol. Metab. 16, 289–309.

    Article  CAS  Google Scholar 

  2. Foster, W. G. (1998). Can. J. Public Health 89, S37-S41.

    PubMed  Google Scholar 

  3. Landrigan, P., Garg, A., and Droller, D. B. J. (2003). Env. Health Perspect. 111, 1678–1682.

    Article  Google Scholar 

  4. Sharara, F. I., Seifer, D. B., and Flaws, J. A. (1998). Fertil. Steril. 70, 613–622.

    Article  PubMed  CAS  Google Scholar 

  5. Vidaeff, A. C. and Sever, L. E. (2005). Reprod. Toxicol. 20, 5–20.

    Article  PubMed  CAS  Google Scholar 

  6. Sweeney, T. (2002). Domest. Anim. Endocrinol. 23, 203–209.

    Article  PubMed  CAS  Google Scholar 

  7. Shapre, R. M. and Franks, S. (2002). Nat. Med. 8, S33-S40.

    Google Scholar 

  8. Andres R. L. and Day, M.-C. (2000). Semin. Neonatol. 5, 231–241

    Article  PubMed  CAS  Google Scholar 

  9. Hofhuis, W., de Jongste, J. C., and Merkus, P. J. F. M. (2003). Arch. Dis. Child. 88, 1086–1090.

    Article  PubMed  CAS  Google Scholar 

  10. Ness, R. B., Grisso, J. A., Hirschinger, N., et al. (1999). N. Engl. J. Med. 340, 333–339.

    Article  PubMed  CAS  Google Scholar 

  11. Shiverick, K. T. and Salafia, C. (1999). Placenta 20, 265–272.

    Article  PubMed  CAS  Google Scholar 

  12. Health Canada Canadian Perinatal Health Report (2000). Minister of Public Works and Government Services Canada: Ottawa, ON, pp. 3–5.

  13. Jensen, M. S., Mabeck, L. M., Toft, G., Thulstrup, A. M. and Bonde, J. P. (2005). Hum. Reprod. 20, 2559–2566.

    Article  PubMed  CAS  Google Scholar 

  14. Jensen, T. K., Henriksen, T. B., Hjollund, N. H., et al. (1998). Am. J. Epidemiol. 148, 992–997.

    PubMed  CAS  Google Scholar 

  15. Jensen, T. K., Jorgensen, N., Punab, M., et al. (2004). Am. J. Epidemiol. 159, 49–58.

    Article  PubMed  Google Scholar 

  16. Storgaard, L., Bonde, J. P., Ernst, E., et al. (2003). Epidemiol. 14, 261–262.

    Article  Google Scholar 

  17. Weinberg, C. R., Wilcox, A. J., and Baird, D. D. (1989). Am. J. Epidemiol. 129, 1072–1078.

    PubMed  CAS  Google Scholar 

  18. Swauger, J. E., Steichen, T. J., Murphy, P. A., and Kinsler, S. (2002). Reg. Toxicol. Pharmacol. 35, 142–156.

    Article  CAS  Google Scholar 

  19. Blackburn, C. W., Peterson, C. A., Hales, H. A., et al. (1994). Reprod. Toxicol. 8, 325–331.

    Article  PubMed  CAS  Google Scholar 

  20. Patil, S. R., Ravindra Patil, S. R., Londonkar, R., and Patil, S. B. (1998). Indian J. Physiol. Pharmacol. 42, 503–508.

    PubMed  CAS  Google Scholar 

  21. Alderete, E., Eskenazi, B., and Sholtz, R. (1995). Epidemiology 6, 403–408.

    Article  PubMed  CAS  Google Scholar 

  22. Augood, C., Duckitt, K., and Templeton, A. A. (1998). Hum. Reprod. 13, 1532–1539.

    Article  PubMed  CAS  Google Scholar 

  23. Baird, D. D. and Wilcox, A. J. (1985). JAMA 253, 2979–2983

    Article  PubMed  CAS  Google Scholar 

  24. Bolumar, F., Olsen, J., and Boldsen, J. (1996). Am. J. Epidemiol. 143, 578–587.

    PubMed  CAS  Google Scholar 

  25. Hassan, M. A. M. and Killick, S. R. (2004). Fertil. Steril. 81, 384–392.

    Article  PubMed  Google Scholar 

  26. Howe, G., Westhoff, C., Vessey, M., and Yeates, D. (1985). Br. Med. J. (Clin. Res. Ed.) 290, 1697–1700.

    Article  CAS  Google Scholar 

  27. Joesoef, M. R., Beral, V., Aral, S. O., Rolfs, R. T., and Cramer, D. W. (1993). Ann. Epidemiol. 3, 592–594.

    Article  PubMed  CAS  Google Scholar 

  28. Olsen, J., Rachootin, P., Schiodt, A. V., and Damsbo, N. (1983). Int. J. Epidemiol. 12, 179–184.

    Article  PubMed  CAS  Google Scholar 

  29. Suonio, S., Saarikoski, S., Kauhanen, O., Metsapelto, A., Terho, J., and Vohlonen, I. (1990). Eur. J. Obstet. Gynecol. Reprod. Biol. 34, 89–95.

    Article  PubMed  CAS  Google Scholar 

  30. Harrison, K. L., Breen, T. M., and Hennessey, J. F. (1990). Aus. N.Z. J. Obstet. Gynaecol. 30, 340–342.

    CAS  Google Scholar 

  31. Klonoff-Cohen, H., Natarajan, J., Marrs, R., and Yee, B. (2001). Hum. Reprod. 16, 1382–1390.

    Article  PubMed  CAS  Google Scholar 

  32. Van Voohris, B. J., Dawson, J. D., Stovall, D. W., Sparks, A. E. T., and Syrop, C. H. (1996). Obstet. Gynecol. 88, 785–791.

    Article  Google Scholar 

  33. Abd, E. L., Mohsen, M. M., Fahim, A. T., Motawi, T. M., and Ismail, N. A. (1997). Phamacol. Res. 35, 181–187.

    Article  Google Scholar 

  34. Weiss, T. and Eckert A. (1989). Hum. Reprod. 4, 482–485.

    PubMed  CAS  Google Scholar 

  35. Younglai, E. V., Foster, W. G., Hughes, E. G., Trim, K., and Jarrell, J. F. (2002). Arch. Environ. Contam. Toxicol. 43, 121–126.

    Article  PubMed  CAS  Google Scholar 

  36. Zenzes, M. T., Puy, L. A., and Bielecki, R. (1997). Fertil. Steril. 68, 76–82.

    Article  PubMed  CAS  Google Scholar 

  37. Lambers, D. S. and Clark, K. E. (1996). Semin. Perinatol. 20, 115–126.

    Article  PubMed  CAS  Google Scholar 

  38. Bodis, J., Hanf, V., Torok, A., Tinneberg, H. R., Borsay, P., and Szabo, I. (1997). Early Pregnancy 3, 34–37.

    PubMed  CAS  Google Scholar 

  39. Miceli, F., Minici, F., Tropea, A., et al. (2005). Biol. Reprod. 72, 628–632.

    Article  PubMed  CAS  Google Scholar 

  40. Mlynarcikova, A., Fickova, M., and Sesukova, S. (2005) Endocr. Regul. 39, 20–31.

    Google Scholar 

  41. Sanders, S. R., Cuneo, S. P., and Turzillo, A. M. (2002). Reprod. Toxicol. 16, 795–800.

    Article  PubMed  CAS  Google Scholar 

  42. Vrsanska, S., Nagyova, E., Mlynarcikova, A., Fickova, M., and Kolena, J. (2003). Physiol. Res. 52, 383–387.

    PubMed  CAS  Google Scholar 

  43. Bergstrom, B. J. and Rose, R. K. (2004). J. Mammol. 85, 1077–1086.

    Article  Google Scholar 

  44. Guzman, C., Cabrera, R., Cardenas, M., Larrea, F., Nathanielsz, P. W., and Zambrano, E. (2006). J. Physiol. 572, 97–108.

    PubMed  CAS  Google Scholar 

  45. Kolibianakis, E. M., Zikopoulos, K., Smitz, J., et al. (2004). Hum. Reprod. 19, 1525–1529.

    Article  PubMed  CAS  Google Scholar 

  46. Matt, D. W., Lee, J., Sarver, P. L., Judd, H. L., and Lu, J. K. H. (1986). Biol. Reprod. 34, 478–487.

    Article  PubMed  CAS  Google Scholar 

  47. Tilly, J. L. (2001). Nat. Rev. Mol. Cell Biol. 2, 838–848.

    Article  PubMed  CAS  Google Scholar 

  48. Hamilton, B. E., Martin, J. A., Ventura, S. J., Sutton, P. D., and Menacker, F. (2005). Natl. Vital. Stat. Rep. 29, 1–17.

    Google Scholar 

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Holloway, A.C., Kellenberger, L.D. & Petrik, J.J. Fetal and neonatal exposure to nicotine disrupts ovarian function and fertility in adult female rats. Endocr 30, 213–216 (2006). https://doi.org/10.1385/ENDO:30:2:213

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  • DOI: https://doi.org/10.1385/ENDO:30:2:213

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