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Levels of zinc and magnesium in senile and diabetic senile cataractous lenses

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Abstract

Zinc and magnesium in serum, hair, and lens were determined in diabetic and nondiabetic patients who have been operated because of senile cataract. Both trace elements were measured by atomic absorption spectrometry, after acidic digestion of the lens and hair samples. Although there was no difference in serum, lens, and hair levels of magnesium between the two groups, the lens levels of zinc in diabetic patients (0.56±0.05 µmol/g dry weight) were significantly higher as compared with nondiabetic group (0.42±0.03 µmol/g dry weight). There was no statistically significant difference in serum and hair levels of zinc between the groups. The increased concentration of zinc in the lens of diabetic patients suggests that zinc might play a role in developmental mechanism of the diabetic senile cataract.

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References

  1. D. Garland, Role of site specific, metal-catalyzed oxidation in lens aging and cataract: a hypothesis, Exp. Eye Res. 50, 677–682 (1990).

    Article  PubMed  CAS  Google Scholar 

  2. M. A. Kass, F. G. Berson, L. A. Gans, D. J. Schanzlin, and B. J. Shingleton, The lens, K. A. Hecht, B. Nichols, and J. V. Bueren eds., American Academy of Ophthalmology, San Francisco, CA, Sect. pp. 102–150 (1990–1991).

    Google Scholar 

  3. V. Rasi, S. Constantini, and A. Moramarco, Inorganic element concentrations in cataractous human lenses, Ann. Ophthalmol. 24, 459–464 (1992).

    PubMed  CAS  Google Scholar 

  4. J. D. Wilmor and D. F. Foster, Diabetes mellitus, in Williams’ Textbook of Endocrinology, R. H. Unger and D. W. Foster eds., W. B. Saunders, Philadelphia, pp. 505–1994 (1992).

    Google Scholar 

  5. A. Stanojevic, V. Hristil, and M. Cuperlovic, Macro and microelements in the cataractous eye lens, Ophthal. Res. 19, 230–234 (1987).

    Article  Google Scholar 

  6. X. Hou and Y. Hou, Determination of 19 elements in human eye lenses, Biol. Trace Element Res. 55, 89–98 (1996).

    Article  CAS  Google Scholar 

  7. A. Sethi, K. Nath, N. Ahmad, K. P. Gupta, and O. Chandra, A study of trace elements in human cataractous lenses and sera, Indian J. Ophthalmol. 35, 201–203 (1987).

    PubMed  CAS  Google Scholar 

  8. V. K. Srivastava, N. Varshney, and D. C. Pandey, Role of trace elements in senile cataract, Acta Ophthalmol. 70, 839–841 (1992).

    Article  CAS  Google Scholar 

  9. J. Brando-Neto, C. A. Silva, N. B. Figueiredo, T. Shuhama, M. B. Hollanda, and J. M. Diniz, Zinc kinetics in insulin-dependent diabetes mellitus patients, BioMetals 13, 141–143 (2000).

    Article  Google Scholar 

  10. H. W. Valk, Magnesium in diabetes mellitus, Neth. J. Med. 54, 139–146 (1999).

    Article  PubMed  Google Scholar 

  11. M. W. Aguilar, J. M. Laborda, M. C. Martinez-Para, et al., Effect of diabetes on the tissular Zn/Cu ratio, J. Trace Elements Med. Biol. 12, 155–158 (1998).

    CAS  Google Scholar 

  12. R. Gupta, V. K. Garg, D. K. Mathur, and R. K. Goyal, Oral zinc therapy in diabetic neuropathy, J Assoc Physicians India 46, 939–942 (1998).

    PubMed  CAS  Google Scholar 

  13. X. Liu and Y. Zhang, Study on change in zinc concentration for diabetic cataractous lenses in rats by means of XIXA, Hsueh. Pao. 21, 134–136 (1990).

    CAS  Google Scholar 

  14. B. L. Vallee and K. H. Falchuk, The biochemical basis of zinc physiology, Physiol. Rev. 73, 79–118 (1993).

    PubMed  CAS  Google Scholar 

  15. G. Chittleborough, A chemist’s view of the analysis of human hair for trace elements, Sci. Total Environ. 14, 53–75 (1980).

    Article  PubMed  CAS  Google Scholar 

  16. M. D. Chen, P. Y. Lin, and C. T. Tsau, Selected metals status in patients with noninsulin-dependent diabetes mellitus, Biol. Trace Element Res. 50, 119–124 (1995).

    Google Scholar 

  17. C. Ruiz, A. Alegria, and R. Barbera, Selenium, zinc and copper in plasma of patients with diabetes mellitus different metabolic control states, J. Trace Elements Med. Biol. 12, 91–95 (1998).

    CAS  Google Scholar 

  18. C. Terres-Martos, A. M. Navarro, and L. F. Martin, Serum zinc and copper concentrations and Cu-Zn ratios in patients with hepatopathies or diabetes, J. Trace Elements Med. Biol. 12, 44–49 (1998).

    CAS  Google Scholar 

  19. N. R. Williams, W. J. Rajput, and J. A. West, Plasma, granulocyte and mononuclear cell copper and zinc in patients with diabetes mellitus, Analyst 120, 887–890 (1995).

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Ophthalmology, Akdeniz University, Antalya, Turkey

    Güray Gündüz & ıclal Yücel

  2. Department of Physiology, School of Medicine, Akdeniz University, Antalya, Turkey

    Filiz Gündüz & Ümit Kemal Şentürk

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  1. Güray Gündüz
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  2. Filiz Gündüz
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  3. ıclal Yücel
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  4. Ümit Kemal Şentürk
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Gündüz, G., Gündüz, F., Yücel, ı. et al. Levels of zinc and magnesium in senile and diabetic senile cataractous lenses. Biol Trace Elem Res 95, 107–112 (2003). https://doi.org/10.1385/BTER:95:2:107

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  • DOI: https://doi.org/10.1385/BTER:95:2:107

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