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Relationship among TNF-α, sICAM-1, and selenium in presurgical patients with abdominal aortic aneurysms

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Abstract

The purpose of our study was to estimate the utility of tumor necrosis factor (TNF), soluble intercellular adhesion molecule-1 (sICAM-1), and selenium (Se) measurements as subsidiary parameters for the diagnosis and differentiation of large aortic abdominal aneurymms (AAAs). The TNF and sICAM-1 levels in AAAs were significantly higher than in the controls. On the contrary, the Se level in AAAs was slightly lower; however, the difference was not significant. sICAM-1 did not correlate with TNF or Se as well as with any physical parameter. TNF was related to body mass index (r=0.375). A negative correlation was found for Se and the aneurysm's diameter (r=−0.382), especially for the height-adjusted diameter (r=−0.418). The results of the present study do not allow one to count TNF and sICAM-1 as markers of AAA advancement. It was shown for the first time that the level of serum Se is low in ruptured aneurysms, but not in the unruptured AAAs.

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Authors and Affiliations

  1. Department of Food Commodities Science and Technology, Clinical Hospital, Medical University, Bialystok, Poland

    Anna M. Witkowska

  2. Department of Bromatology, Clinical Hospital, Medical University, Bialystok, Poland

    Maria H. Borawska

  3. Department of Vascular Surgery and Transplantation, Clinical Hospital, Medical University, Bialystok, Poland

    Marek Gacko

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  1. Anna M. Witkowska
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  2. Maria H. Borawska
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  3. Marek Gacko
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Witkowska, A.M., Borawska, M.H. & Gacko, M. Relationship among TNF-α, sICAM-1, and selenium in presurgical patients with abdominal aortic aneurysms. Biol Trace Elem Res 114, 31–40 (2006). https://doi.org/10.1385/BTER:114:1:31

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  • DOI: https://doi.org/10.1385/BTER:114:1:31

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