Abstract
Traditional lactic acid fermentation suffers from low productivity and low product purity. Cell-recycle fermentation has become one of the methods to obtain high cell density, which results in higher productivity. Lactic acid fermentation was investigated in a cell-recycle membrane bioreactor at higher substrate concentrations of 100 and 120 g/dm3. A maximum cell density of 145 g/dm3 and a maximum productivity of 34 g/(dm3…h) were achieved in cell-recycle fermentation. In spite of complete consumption of substrate, there was a continuous increase in cell density in cell-recycle fermentation. Control of cell density in cell-recycle fermentation was attempted by cell bleeding and reduction in yeast extract concentration.
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Choudhury, B., Swaminathan, T. Lactic acid fermentation in cell-recycle membrane bioreactor. Appl Biochem Biotechnol 128, 171–183 (2006). https://doi.org/10.1385/ABAB:128:2:171
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DOI: https://doi.org/10.1385/ABAB:128:2:171